Insulin Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LEU-1045   ASN-1046  4.5 4.5 -2.8 7.1 82.1 75.6 19.0  ASN-1046   GLU-1047  6.1 6.9 -18.0 13.8 24.9 27.3 47.0  GLU-1047   ALA-1048  5.5 5.9 -11.7 8.2 87.6 93.3 13.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  VAL-1065   VAL-1066  5.7 5.6 17.8 -38.3 123.7 119.4 153.6  VAL-1066   SER-1067  8.4 7.9 -1.6 8.3 43.0 50.5 -34.2  SER-1067   LYS-1068  7.2 7.3 -0.3 4.6 46.3 59.0 35.2  LYS-1068   GLY-1069  10.4 10.8 -29.7 14.6 100.5 106.8 -1.9  GLY-1069   GLN-1070  12.4 12.9 -69.8 62.1 132.4 140.5 -54.0  GLN-1070   PRO-1071  13.1 13.3 -13.0 -1.5 142.4 136.9 -77.1  GLN-1070   PRO-1071  13.1 13.3 -13.0 -1.5 142.4 136.9 -77.1 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLN-1070   PRO-1071  13.1 13.3 -13.0 -1.5 142.4 136.9 -77.1  GLN-1070   PRO-1071  13.1 13.3 -13.0 -1.5 142.4 136.9 -77.1  PRO-1071   THR-1072  12.6 12.7 -7.6 -5.9 98.8 96.0 23.7  THR-1072   LEU-1073  8.9 9.0 10.2 -2.7 7.9 18.5 66.8  LEU-1073   VAL-1074  7.9 7.4 10.1 -10.9 78.3 82.3 2.4  VAL-1074   VAL-1075  4.5 4.2 -5.9 12.9 157.0 155.6 47.9  VAL-1075   MET-1076  5.5 5.5 -11.4 12.7 120.9 121.8 23.9  MET-1076   GLU-1077  3.5 3.4 -3.7 -6.9 154.9 154.0 -96.0  GLU-1077   LEU-1078  4.5 4.5 -4.9 14.8 57.7 54.4 -89.2  GLU-1077   LEU-1078  4.5 4.5 -4.9 14.8 57.7 54.4 -89.2 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLU-1077   LEU-1078  4.5 4.5 -4.9 14.8 57.7 54.4 -89.2  GLU-1077   LEU-1078  4.5 4.5 -4.9 14.8 57.7 54.4 -89.2  LEU-1078   MET-1079  4.7 4.5 -8.7 -3.0 36.4 41.1 69.5  MET-1079   ALA-1080  2.3 1.9 -16.5 2.4 45.4 53.9 72.4  ALA-1080   HIS-1081  4.4 4.5 -12.4 26.3 69.4 70.6 -11.3 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees