Camp-Specific 3',5'-Cyclic Phosphodiesterase 4B

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-281   SER-282  3.7 4.0 -4.7 11.0 113.8 116.8 -8.2
 SER-282   ASN-283  3.4 3.7 -6.5 0.8 170.5 178.0 -10.4
 ASN-283   GLN-284  4.3 3.9 5.4 0.3 75.6 72.6 1.8
 GLN-284   PHE-285  7.8 7.4 -6.2 9.1 94.3 93.3 -8.4
 PHE-285   LEU-286  7.5 7.5 -4.4 8.5 146.4 149.4 44.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-292   LEU-293  5.7 5.7 0.6 10.6 86.0 81.2 -1.5
 LEU-293   ALA-294  2.6 2.8 -12.6 8.9 77.9 77.7 8.1
 ALA-294   LEU-295  2.5 2.6 -6.2 1.3 9.3 11.5 33.4
 LEU-295   MET-296  3.2 3.1 -5.3 10.5 67.7 68.8 -41.9
 MET-296   TYR-297  1.0 0.9 -5.4 7.3 94.4 100.0 -25.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-300   SER-301  7.5 7.3 3.1 0.1 55.3 58.5 16.9
 SER-301   VAL-302  7.2 6.9 -8.2 6.9 78.2 77.8 -26.0
 VAL-302   LEU-303  3.5 3.2 -7.8 8.1 121.8 122.5 -15.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLN-405   TRP-406  3.7 4.0 -4.7 2.4 170.0 167.6 -34.0
 TRP-406   THR-407  4.0 4.1 -2.0 -0.9 102.7 102.1 23.9
 THR-407   ASP-408  2.3 2.3 7.7 5.4 86.3 90.7 31.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 MET-426   GLU-427  16.7 16.8 -11.0 12.4 141.1 144.5 10.3
 GLU-427   ILE-428  17.3 17.5 5.9 18.4 54.1 57.5 161.5
 ILE-428   SER-429  15.2 15.2 -7.3 3.8 107.4 91.6 -0.6
 SER-429   PRO-430  13.8 12.8 31.4 -23.0 6.3 23.1 113.7
 PRO-430   MET-431  15.3 13.2 152.6 -174.2 48.0 58.1 -111.8
 MET-431   CYS-432  11.7 10.9 10.4 -2.2 94.6 96.6 -71.9
 CYS-432   ASP-433  10.2 10.4 -6.3 -7.6 108.0 115.2 -91.6
 ASP-433   LYS-434  13.6 13.5 25.7 -13.8 17.7 13.4 143.9
 LYS-434   HIS-435  12.9 12.6 16.5 -33.5 52.2 45.7 -141.4
 HIS-435   THR-436  16.5 15.8 19.9 -0.2 69.1 94.2 117.0
 THR-436   ALA-437  16.6 15.9 8.2 -4.0 76.6 85.9 53.9
 ALA-437   SER-438  13.5 12.5 11.0 -28.7 25.6 24.2 -146.7
 SER-438   VAL-439  12.6 11.9 -14.0 2.2 76.6 85.4 34.6
 VAL-439   GLU-440  8.8 8.4 7.1 -13.6 66.3 68.1 4.1
 GLU-440   LYS-441  9.9 10.2 10.3 -1.6 117.3 123.3 -47.3
 LYS-441   SER-442  13.3 13.3 -6.4 5.4 27.2 34.1 17.9
 SER-442   GLN-443  11.6 11.3 -8.2 -0.3 92.8 98.1 61.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees