Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-214   THR-215  9.8 10.1 2.5 -2.9 130.9 125.8 7.7
 THR-215   VAL-216  8.3 8.5 2.2 -0.7 69.0 66.8 -73.0
 VAL-216   ALA-217  7.6 7.9 -3.0 -5.0 36.3 37.2 138.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-218   GLU-219  10.5 10.7 0.5 -9.0 51.9 49.7 -139.0
 GLU-219   GLY-220  13.9 14.0 6.6 -1.7 40.9 49.3 202.6
 GLY-220   ASP-221  14.6 14.7 0.0 -3.8 136.7 140.0 -68.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-240   ILE-241  16.4 16.6 -7.9 14.3 119.0 124.3 124.7
 ILE-241   ALA-242  14.2 14.2 0.6 0.0 35.9 34.3 23.5
 ALA-242   THR-243  14.8 14.9 4.3 -2.0 84.9 81.1 -18.8
 THR-243   ALA-244  13.8 13.9 -10.4 0.5 48.6 48.4 126.9
 ALA-244   GLU-245  12.8 12.9 1.6 -1.1 70.3 71.7 -42.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ARG-253   LYS-254  18.2 18.0 2.3 11.9 170.5 175.8 -374.8
 LYS-254   SER-255  17.2 16.8 7.1 -21.4 111.2 103.1 443.1
 SER-255   TYR-256  15.4 15.1 10.1 2.4 81.0 85.3 41.4
 TYR-256   ASP-257  11.8 11.4 -1.6 4.2 41.9 37.7 -25.6
 ASP-257   SER-258  11.4 11.3 -1.1 -2.3 98.9 95.4 -2.9
 SER-258   VAL-259  13.7 13.6 -0.5 -1.1 129.7 127.8 30.5
 VAL-259   ILE-260  11.3 11.4 1.9 0.4 118.1 115.5 -74.0
 ILE-260   ARG-261  8.4 8.4 2.3 -3.8 122.5 123.3 57.8
 ARG-261   GLU-262  11.2 11.3 -1.7 -1.6 125.9 124.6 4.2
 GLU-262   LEU-263  12.6 13.0 3.0 -1.7 78.4 75.0 -36.4
 LEU-263   LEU-264  9.6 10.0 -7.4 8.4 39.3 39.1 -17.6
 LEU-264   GLN-265  9.9 10.1 -17.0 4.6 80.4 79.6 73.0
 GLN-265   LYS-266  13.7 13.9 14.0 -5.1 56.0 49.6 25.2
 LYS-266   PRO-267  13.8 14.1 0.6 -0.4 103.7 101.6 32.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PHE-275   MET-276  4.5 4.6 -19.6 17.1 106.2 105.4 -137.3
 MET-276   ARG-277  6.8 6.8 14.2 -12.8 101.3 103.7 -20.8
 ARG-277   SER-278  9.6 9.4 7.7 2.0 38.9 37.2 77.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-280   SER-281  10.8 10.5 -7.5 3.3 61.5 65.6 -25.5
 SER-281   ARG-282  7.5 7.3 -7.3 1.1 24.3 28.8 157.4
 ARG-282   GLU-283  9.7 9.5 4.7 -5.5 134.1 138.9 13.4
 GLU-283   LEU-284  10.6 10.2 -7.4 6.4 72.4 71.2 36.4
 LEU-284   ILE-285  7.3 7.2 1.1 -1.4 129.1 126.3 1.5
 ILE-285   ALA-286  5.6 5.1 3.2 -2.0 156.7 156.8 -34.5
 ALA-286   ALA-287  8.2 7.8 -2.0 2.1 60.4 55.4 20.7
 ALA-287   ALA-288  7.8 7.6 8.0 -6.1 108.4 109.8 -32.3
 ALA-288   SER-289  4.0 3.9 -9.6 5.3 33.7 34.1 78.1
 SER-289   ARG-290  4.4 4.0 12.1 -21.1 146.5 145.6 179.0
 ARG-290   ALA-291  6.5 6.2 44.9 -35.7 110.3 105.4 -115.1
 ALA-291   ASN-292  5.2 4.9 -12.1 16.0 81.8 73.3 44.5
 ASN-292   ALA-293  1.4 1.6 -6.9 -13.9 126.8 134.6 -332.9
 ALA-293   SER-294  2.8 3.1 -10.9 -8.9 118.1 122.2 -203.7
 SER-294   PHE-295  3.7 3.7 -16.7 27.2 148.5 138.0 220.9
 PHE-295   THR-296  4.5 4.8 12.1 -8.7 51.9 51.8 111.2
 THR-296   TRP-297  5.9 6.1 -5.3 2.5 138.1 142.9 -97.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees