Carboxyl-Terminal Src Kinase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-78   LEU-79  3.6 3.4 -17.5 28.5 122.7 121.2 18.8
 LEU-79   MET-80  1.1 1.1 -8.5 2.4 65.8 60.9 12.7
 MET-80   PRO-81  1.9 3.4 -16.7 -6.6 10.8 14.5 42.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-174   GLY-175  2.2 3.2 -0.6 -12.9 62.5 52.5 14.7
 GLY-175   THR-176  5.6 5.9 -20.0 -15.6 10.1 12.2 73.2
 THR-176   VAL-177  4.6 3.9 14.8 -20.3 117.8 101.6 9.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-200   ILE-201  10.2 7.8 25.1 -31.1 85.8 84.5 5.7
 ILE-201   GLY-202  13.2 11.1 137.7 -51.3 113.8 102.5 -46.3
 GLY-202   LYS-203  14.7 13.8 56.7 10.9 134.5 46.9 14.9
 LYS-203   GLY-204  14.7 15.0 160.7 94.1 132.4 97.9 229.8
 GLY-204   GLU-205  16.5 13.7 -2.0 -74.0 35.6 103.7 38.8
 GLU-205   PHE-206  18.1 10.4 61.8 4.9 125.9 143.1 -94.5
 PHE-206   GLY-207  15.1 10.2 -16.0 142.6 111.3 43.3 -121.7
 GLY-207   ASP-208  12.5 10.1 27.4 4.0 15.3 124.1 31.2
 ASP-208   VAL-209  11.6 7.9 -152.4 -1.6 98.8 99.3 -30.8
 VAL-209   MET-210  11.3 8.3 -1.1 0.7 155.9 163.7 2.3
 MET-210   LEU-211  9.1 7.0 13.1 -17.5 70.4 77.6 -4.1
 LEU-211   GLY-212  9.5 8.6 -12.2 7.2 81.6 95.1 1.1
 GLY-212   ASP-213  7.7 7.9 11.7 -3.9 69.3 76.7 13.1
 ASP-213   TYR-214  8.8 10.5 8.5 -4.1 137.7 131.4 -4.9
 TYR-214   ARG-215  10.5 12.6 3.0 -3.5 74.6 76.1 0.9
 ARG-215   GLY-216  13.2 15.9 3.5 -8.2 36.2 47.3 -7.4
 GLY-216   ASN-217  13.3 15.9 10.5 7.2 86.2 99.1 -0.4
 ASN-217   LYS-218  13.9 15.6 -4.8 -12.4 72.8 83.8 5.2
 LYS-218   VAL-219  12.6 13.5 -19.5 24.6 17.9 19.3 -10.9
 VAL-219   ALA-220  12.3 12.3 1.3 -3.9 100.4 95.4 -0.5
 ALA-220   VAL-221  11.7 10.8 -11.0 9.2 43.9 45.9 7.3
 VAL-221   LYS-222  8.7 7.4 -7.7 8.3 67.5 68.1 0.4
 LYS-222   CYS-223  9.2 7.0 -17.8 37.3 53.0 56.2 -19.0
 CYS-223   ILE-224  7.3 4.0 30.4 -76.7 117.2 136.7 73.9
 ILE-224   LYS-225  9.7 4.9 -23.5 14.5 92.0 61.0 1.0
 LYS-225   ASN-226  11.4 5.0 90.9 -160.9 149.2 154.0 132.0
 ASN-226   ASP-227  12.9 7.5 -48.0 86.5 39.9 94.4 -31.5
 ASP-227   ALA-228  10.2 10.2 53.3 20.9 115.9 137.0 -166.5
 ALA-228   THR-229  9.7 12.5 4.0 11.9 127.2 85.4 -17.6
 THR-229   ALA-230  7.4 12.4 6.3 -123.7 68.4 89.9 -87.9
 ALA-230   GLN-231  6.1 8.7 -60.8 4.0 64.7 53.2 53.3
 GLN-231   ALA-232  8.8 9.5 -0.9 4.5 131.2 110.2 0.6
 ALA-232   PHE-233  11.0 12.7 11.3 -21.2 62.7 49.8 -1.7
 PHE-233   LEU-234  8.4 10.9 13.2 3.8 120.8 116.3 -9.7
 LEU-234   ALA-235  8.6 8.8 6.3 -5.9 99.9 119.7 7.6
 ALA-235   GLU-236  12.1 12.1 -1.9 14.9 141.0 129.0 15.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees