Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-683   LYS-684  3.1 4.3 8.0 -9.4 102.5 107.8 -17.0
 LYS-684   GLU-685  5.9 7.1 9.0 8.4 34.7 31.7 78.2
 GLU-685   THR-686  8.8 9.7 -12.5 7.2 94.1 100.6 -16.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-689   LYS-690  10.9 10.8 15.4 -18.5 151.4 157.1 14.0
 LYS-690   ILE-691  11.1 11.4 -27.9 25.4 50.8 51.4 -68.0
 ILE-691   LYS-692  12.5 12.2 -6.9 11.0 34.4 27.0 -5.8
 LYS-692   VAL-693  12.6 12.1 8.3 -10.2 96.3 89.5 39.6
 VAL-693   LEU-694  12.6 12.2 -7.3 8.1 29.9 43.0 4.0
 LEU-694   GLY-695  10.1 9.2 -7.7 -30.1 62.5 54.5 93.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-701   VAL-702  14.2 14.0 -24.1 19.8 77.4 73.7 42.9
 VAL-702   TYR-703  10.4 10.2 8.1 -11.1 86.5 81.2 16.1
 TYR-703   LYS-704  9.5 9.4 -22.6 50.9 97.5 91.8 -9.3
 LYS-704   GLY-705  7.4 7.4 8.9 -0.4 45.0 30.0 13.2
 LYS-704   GLY-705  7.4 7.4 8.9 -0.4 45.0 30.0 13.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-704   GLY-705  7.4 7.4 8.9 -0.4 45.0 30.0 13.2
 LYS-704   GLY-705  7.4 7.4 8.9 -0.4 45.0 30.0 13.2
 GLY-705   LEU-706  7.7 7.7 -1.8 -1.4 106.6 110.8 22.6
 LEU-706   TRP-707  7.5 7.5 -11.6 1.2 163.6 159.1 -54.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-716   PRO-717  6.5 6.5 14.9 -6.3 55.8 50.6 16.3
 PRO-717   VAL-718  5.2 5.3 4.2 -0.8 96.5 95.7 2.1
 VAL-718   ALA-719  2.5 2.7 -4.8 14.1 117.2 125.2 10.5
 ALA-719   ILE-720  4.2 4.2 5.2 -9.7 39.5 35.5 -10.9
 ALA-719   ILE-720  4.2 4.2 5.2 -9.7 39.5 35.5 -10.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-719   ILE-720  4.2 4.2 5.2 -9.7 39.5 35.5 -10.9
 ALA-719   ILE-720  4.2 4.2 5.2 -9.7 39.5 35.5 -10.9
 ILE-720   LYS-721  7.1 7.0 -5.7 14.6 69.0 69.1 -35.0
 LYS-721   GLU-722  10.0 9.9 -3.0 40.5 137.3 140.4 127.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-743   SER-744  11.7 11.1 -12.9 44.6 84.4 93.0 -1.4
 SER-744   VAL-745  15.2 13.9 135.6 53.8 39.3 46.6 836.6
 VAL-745   ASP-746  14.9 14.2 -40.0 26.7 92.8 122.7 47.3
 ASP-746   ASN-747  14.3 16.1 132.7 87.7 40.1 25.7 -663.1
 ASN-747   PRO-748  15.0 16.0 -2.3 -5.7 127.8 100.9 -72.9
 PRO-748   HIS-749  13.5 13.6 12.2 5.3 43.7 50.2 64.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-753   LEU-754  7.1 7.5 -17.8 12.8 127.7 132.3 -7.1
 LEU-754   GLY-755  4.1 4.6 0.6 13.0 27.5 26.0 57.0
 GLY-755   ILE-756  4.8 4.7 -21.8 4.9 82.2 79.9 13.6
 ILE-756   CYS-757  6.9 7.3 -12.9 13.0 127.9 130.1 -2.6
 CYS-757   LEU-758  7.7 8.3 -1.7 -13.1 103.7 101.3 -1.4
 LEU-758   THR-759  10.8 11.4 -28.9 20.2 94.8 110.7 15.7
 THR-759   SER-760  13.3 13.7 -25.2 24.7 95.9 79.5 -21.9
 SER-760   THR-761  17.1 17.4 -5.6 17.7 64.4 32.3 -55.9
 THR-761   VAL-762  16.2 16.3 -13.4 -8.1 87.0 88.2 -17.4
 VAL-762   GLN-763  13.1 13.5 -6.2 -2.5 28.4 38.4 35.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees