Proto-Oncogene Tyrosine-Protein Kinase Src

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 MET-314   LYS-315  3.4 3.7 -1.0 -1.3 82.4 83.6 -0.1
 LYS-315   LYS-316  5.7 5.9 -1.8 6.3 150.7 151.9 23.6
 LYS-316   LEU-317  6.9 7.1 -15.6 26.7 131.4 129.7 54.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-322   VAL-323  4.6 4.5 -5.6 11.1 161.6 166.2 49.2
 VAL-323   GLN-324  5.4 5.1 6.0 -16.7 69.2 70.8 -52.3
 GLN-324   LEU-325  3.7 3.7 -12.3 21.9 154.4 158.8 62.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-337   THR-338  2.3 2.4 14.8 -2.7 17.7 24.0 79.9
 THR-338   GLU-339  4.2 4.2 -0.4 -0.2 95.7 88.2 -29.3
 GLU-339   TYR-340  7.3 7.6 31.3 -28.8 100.8 96.7 10.1
 TYR-340   MET-341  10.5 10.7 22.0 -8.7 38.5 37.2 97.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-401   VAL-402  9.4 9.2 0.4 -4.8 81.7 85.3 -2.8
 VAL-402   ALA-403  8.0 7.9 2.4 -6.4 23.8 27.5 -35.5
 ALA-403   ASP-404  8.0 8.0 -9.6 156.9 94.8 87.4 194.6
 ASP-404   PHE-405  9.3 9.8 22.0 14.5 123.6 17.5 214.3
 PHE-405   GLY-406  8.0 11.8 -9.1 108.9 115.3 101.1 -650.5
 GLY-406   LEU-407  10.9 13.6 52.7 58.2 125.8 78.6 -347.6
 GLY-421   ALA-422  28.0 26.3 -87.5 -57.9 123.3 134.6 -798.1
 ALA-422   LYS-423  27.2 24.5 -4.6 13.4 57.5 61.1 13.1
 LYS-423   PHE-424  26.2 23.6 35.4 10.5 111.2 155.7 -261.7
 PHE-424   PRO-425  23.5 23.2 5.6 -61.0 157.9 113.3 354.2
 PRO-425   ILE-426  22.1 22.1 3.5 22.4 154.8 167.0 -157.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees