Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ARG-203   VAL-204  8.3 8.3 13.1 -20.8 80.3 81.0 -13.6  VAL-204   VAL-205  7.3 7.0 20.3 -27.8 53.7 48.1 -20.9  VAL-205   PRO-206  4.9 4.4 4.6 -5.8 123.2 123.9 23.4  PRO-206   SER-207  2.6 2.7 10.8 2.1 91.4 85.4 -14.0  SER-207   ASP-208  5.9 6.1 9.4 11.4 52.4 45.3 153.6  ASP-208   THR-209  8.4 8.4 -14.6 4.3 66.6 70.3 -80.0  THR-209   LEU-210  9.7 9.4 -2.2 10.2 109.1 101.1 15.0  LEU-210   GLN-211  7.2 6.9 -24.7 43.5 161.9 145.1 136.0  GLN-211   ALA-212  8.3 8.0 -7.9 6.7 96.2 84.8 -105.4  ALA-212   ARG-213  12.1 11.7 -16.5 6.5 74.3 74.5 -41.6  ARG-213   ALA-214  11.5 11.5 11.5 -5.5 42.6 41.1 41.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ILE-340   LYS-341  6.8 6.9 -10.1 7.2 74.1 80.3 58.0  LYS-341   LEU-342  3.1 3.2 -12.5 8.1 151.1 146.4 -65.9  LEU-342   GLN-343  0.6 0.3 -21.5 22.6 83.6 75.1 12.1  GLN-343   SER-344  3.1 3.6 5.8 14.4 82.4 84.0 10.2  SER-344   PRO-345  5.5 5.6 -15.9 9.2 28.4 31.5 44.0  PRO-345   GLU-346  8.3 8.3 1.7 -3.0 100.8 100.9 24.6  GLU-346   VAL-347  10.4 10.4 11.7 -9.1 66.5 62.6 24.9 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLY-473   ASP-474  6.4 6.4 1.6 -1.5 20.4 20.2 3.3  ASP-474   ALA-475  4.3 4.3 -0.7 1.1 104.5 104.4 6.0  ALA-475   PRO-476  2.4 2.5 -1.4 2.9 106.3 106.5 37.7  PRO-476   GLY-477  2.2 2.3 14.0 23.2 17.6 20.1 312.0  GLY-477   ARG-478  2.6 3.4 25.4 -38.1 52.8 50.0 -67.6  ARG-478   TYR-479  4.3 4.2 -52.0 28.2 150.6 153.4 -192.2  TYR-479   ASP-480  4.4 4.6 -22.1 17.8 136.9 131.8 -4.7 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees