Importin Alpha Subunit

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-452   GLU-453  3.1 3.1 5.8 -2.3 77.3 77.4 40.7
 GLU-453   ASN-454  6.8 6.8 -6.5 7.2 162.6 164.5 4.9
 ASN-454   ILE-455  6.2 6.2 15.7 -19.0 87.8 85.0 10.1
 ILE-455   LEU-456  5.2 5.3 4.7 1.2 67.1 67.6 9.5
 ILE-455   LEU-456  5.2 5.3 4.7 1.2 67.1 67.6 9.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-455   LEU-456  5.2 5.3 4.7 1.2 67.1 67.6 9.5
 ILE-455   LEU-456  5.2 5.3 4.7 1.2 67.1 67.6 9.5
 LEU-456   LYS-457  8.1 8.3 -7.8 7.2 55.1 49.6 -0.6
 LYS-457   MET-458  10.3 10.4 -10.3 5.0 44.6 45.0 3.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLY-459   GLU-460  11.4 11.1 -10.4 7.5 81.5 81.7 2.9
 GLU-460   ALA-461  13.9 13.8 1.0 -1.8 31.4 30.9 -10.8
 ALA-461   ASP-462  14.6 14.6 11.0 -0.6 70.7 69.3 53.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-472   ASN-473  13.7 13.4 2.1 -6.2 72.0 72.9 -30.4
 ASN-473   ALA-474  9.9 9.7 17.5 -13.7 18.9 20.7 40.6
 ALA-474   ASP-475  10.3 10.2 0.6 3.3 52.6 52.9 39.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-485   ILE-486  1.1 1.1 -2.9 3.1 113.6 111.6 19.2
 ILE-486   PHE-487  4.1 4.1 -6.7 3.2 42.4 43.2 37.8
 PHE-487   ASN-488  6.2 6.3 8.2 -11.7 122.3 126.8 8.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 CYS-489   GLN-490  7.0 6.8 2.3 -6.0 78.4 78.3 -3.1
 GLN-490   GLN-491  9.8 9.7 2.4 10.0 45.1 35.7 102.6
 GLN-491   ASN-492  10.3 9.7 -13.6 8.6 72.3 78.0 -41.7
 ASN-492   GLU-493  11.3 11.1 -13.5 8.4 92.1 97.7 -50.3
 GLU-493   ASN-494  15.0 14.8 4.1 -1.1 152.0 149.0 -1.2
 ASN-494   ASP-495  15.5 15.5 3.7 -11.3 106.1 106.0 92.3
 ASP-495   LYS-496  16.8 16.9 11.1 -1.4 139.3 148.0 -92.0
 LYS-496   ILE-497  15.2 15.6 -14.1 15.8 102.4 97.6 -10.2
 ILE-497   TYR-498  11.8 12.0 6.5 12.0 56.2 65.5 10.6
 TYR-498   GLU-499  12.1 12.8 -20.2 6.4 63.7 51.4 19.9
 GLU-499   LYS-500  14.4 14.7 5.1 -10.3 125.7 127.0 -37.8
 LYS-500   ALA-501  11.6 11.7 -8.4 7.2 119.9 117.6 6.3
 ALA-501   TYR-502  9.4 9.4 4.0 4.2 74.4 76.4 -3.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees