Basic Fibroblast Growth Factor Receptor 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  MET-532   GLU-533  3.1 2.8 -10.2 7.0 121.7 122.0 -4.0  GLU-533   MET-534  5.0 4.6 1.5 -3.9 125.1 120.6 76.2  MET-534   MET-535  7.6 7.2 -0.5 0.8 58.6 60.8 -9.9 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  MET-537   ILE-538  9.6 9.1 10.9 -13.8 37.5 36.8 -36.8  ILE-538   GLY-539  10.8 9.9 147.4 -143.8 73.2 79.8 33.5  GLY-539   LYS-540  10.9 11.6 2.4 1.9 19.6 26.7 61.9  LYS-540   HIS-541  11.2 11.3 -4.1 2.6 136.0 138.0 -52.2  HIS-541   LYS-542  12.2 12.2 5.8 -16.3 30.9 34.8 -48.7 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ILE-544   ILE-545  8.0 7.7 15.1 -12.4 100.9 104.3 -50.1  ILE-545   ASN-546  4.6 4.3 -10.1 -9.9 21.4 10.8 162.7  ASN-546   LEU-547  5.9 5.5 8.7 7.0 123.0 121.3 -24.2 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLU-562   TYR-563  5.5 5.4 -4.7 0.8 41.6 43.2 19.4  TYR-563   ALA-564  5.9 5.8 11.8 -17.9 149.1 148.6 80.5  ALA-564   SER-565  3.9 4.2 11.8 -12.0 138.4 134.9 -42.4 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees