Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  SER-207   ASP-208  2.3 2.9 -0.2 -2.9 92.7 92.5 -3.7  ASP-208   THR-209  2.5 2.5 -25.7 4.0 71.4 71.8 33.9  THR-209   LEU-210  5.5 5.6 -7.6 23.0 142.2 149.8 51.1  LEU-210   GLN-211  6.4 6.5 25.3 -29.6 78.7 67.9 -3.7 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LEU-342   GLN-343  3.3 3.7 8.0 -12.3 166.5 156.6 22.9  GLN-343   SER-344  1.9 1.4 -14.2 -15.6 78.0 81.1 58.5  SER-344   PRO-345  3.4 3.1 -1.5 -15.3 24.9 42.7 76.7 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLY-473   ASP-474  11.8 11.9 -6.2 5.5 121.1 122.7 1.1  ASP-474   ALA-475  8.7 8.7 22.6 -5.7 18.0 15.8 75.1  ALA-475   PRO-476  8.3 8.1 10.5 -1.3 71.1 76.0 25.8  PRO-476   GLY-477  7.4 7.9 -15.3 72.5 113.4 102.5 55.0  GLY-477   ARG-478  4.1 5.4 -64.2 42.5 98.1 147.2 -80.0  ARG-478   TYR-479  4.1 4.7 -64.4 17.5 96.1 88.9 8.6  TYR-479   ASP-480  4.9 5.0 12.6 -16.7 40.1 36.6 1.5 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees