Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-78   CYS-79  6.8 7.3 -24.2 6.6 136.2 125.9 -77.6
 CYS-79   VAL-80  5.7 6.2 -3.7 22.0 85.5 83.8 -15.2
 VAL-80   ASN-81  1.9 2.4 -2.1 -18.2 38.4 40.6 128.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-86   GLY-87  3.7 3.3 -7.1 -5.1 84.6 83.9 -26.7
 GLY-87   LEU-88  0.4 0.5 -7.0 8.7 121.7 120.3 -3.9
 LEU-88   LEU-89  4.1 3.8 16.2 -20.0 51.9 49.6 -12.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 MET-108   GLU-109  3.6 3.6 3.4 -2.6 129.0 125.2 14.8
 GLU-109   LEU-110  1.8 1.6 9.2 -20.0 111.0 112.9 64.8
 LEU-110   MET-111  4.8 4.5 -0.6 2.6 99.0 90.8 41.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-333   PRO-334  7.7 8.4 -7.1 15.9 99.1 106.4 10.7
 PRO-334   PRO-335  3.9 4.9 17.9 -15.0 55.7 51.4 -6.1
 PRO-335   LYS-336  3.2 4.7 173.6 -94.3 128.5 112.8 -326.5
 GLU-350   GLU-351  28.1 28.0 33.6 4.5 112.5 96.8 -67.4
 GLU-351   TRP-352  25.7 25.7 9.1 6.1 66.9 67.6 29.2
 TRP-352   LYS-353  22.8 22.6 14.8 -3.8 22.5 22.1 73.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees