Beta-Secretase
(All numbering and residues are taken from first PDB file)
Bending Residue Dihedral Analysis
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
TYR-60
ARG-61
12.6
12.5
12.3
-10.5
156.6
156.9
-22.2
ARG-61
ASP-62
10.4
10.1
-17.1
2.7
98.0
98.5
17.8
ASP-62
LEU-63
7.2
7.0
-8.8
12.6
47.8
41.7
-19.2
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
GLU-79
LEU-80
1.7
1.6
-6.3
5.3
99.4
102.4
-21.2
LEU-80
GLY-81
2.7
2.5
6.7
-12.3
65.1
65.7
-8.3
GLY-81
THR-82
6.2
5.9
-12.2
8.0
78.5
74.6
41.1
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
GLU-104
SER-105
5.9
6.1
-13.8
12.2
115.2
115.6
16.7
SER-105
ASP-106
5.5
5.5
1.1
-5.4
41.0
46.3
-37.9
ASP-106
LYS-107
8.0
8.1
-2.7
-4.0
122.7
125.1
-35.4
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
PHE-109
ILE-110
2.0
2.5
-5.6
8.1
20.3
15.2
1.8
ILE-110
ASN-111
3.0
3.5
-20.1
0.9
50.5
57.2
66.4
ASN-111
GLY-112
0.7
0.6
-11.9
22.2
63.1
49.5
-40.2
GLY-112
SER-113
3.0
3.1
-8.8
4.4
115.5
109.5
11.3
SER-113
ASN-114
5.4
5.6
-0.3
1.7
105.6
103.6
6.8
ASN-114
TRP-115
6.8
7.1
18.2
-19.7
20.8
22.4
-0.6
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees