Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-124   TYR-125  2.8 3.6 -3.9 -2.3 83.5 80.4 20.1
 TYR-125   ILE-126  1.9 1.6 -4.7 -3.5 33.5 39.0 26.1
 ILE-126   CYS-127  2.2 1.8 -7.3 2.9 35.0 35.6 -5.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-131   ARG-132  5.0 4.7 -4.7 12.4 136.5 140.0 78.5
 ARG-132   TYR-133  5.7 4.3 -9.2 -11.4 147.8 156.1 -103.6
 TYR-133   TYR-134  5.3 4.5 -12.4 -7.3 119.8 116.5 -31.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-323   PRO-324  4.1 4.3 -12.1 -3.7 45.8 43.4 42.0
 PRO-324   GLY-325  2.8 3.2 -6.8 21.0 27.2 24.6 -61.9
 GLY-325   ALA-326  2.5 3.0 4.8 0.8 136.5 129.8 5.6
 ALA-326   ASN-327  2.9 3.2 -34.4 34.9 29.9 25.9 -2.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-331   CYS-332  8.7 9.9 40.1 6.5 29.5 70.8 159.1
 CYS-332   ALA-333  8.7 8.9 -30.6 -15.4 134.5 135.6 -140.5
 ALA-333   LEU-334  7.1 7.5 14.5 -9.0 57.3 63.0 20.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees