Insulin-Like Growth Factor 1 Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-456   SER-457  4.9 6.1 15.9 40.7 20.8 31.7 74.4
 SER-457   CYS-458  5.4 7.1 -175.5 -175.1 115.8 109.2 -15.4
 CYS-458   GLU-459  2.0 4.1 -124.7 -90.1 141.2 130.2 -8.6
 GLU-459   SER-460  1.3 4.1 5.6 100.6 89.3 55.4 90.4
 SER-460   ASP-461  4.8 6.1 -6.9 -6.9 168.7 164.3 -23.5
 ASP-461   VAL-462  6.8 6.4 26.0 -22.8 72.2 76.3 -8.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-507   TYR-508  13.0 13.5 173.2 5.7 25.2 50.5 220.6
 TYR-508   ASP-509  14.0 10.2 -150.2 76.6 128.5 148.4 -81.8
 ASP-509   GLY-510  12.0 12.4 -38.8 7.8 147.6 139.9 -38.1
 GLY-510   GLN-511  13.9 11.9 48.1 110.2 51.8 70.2 114.7
 GLN-511   ASP-512  15.2 15.7 -85.0 -6.7 68.7 175.0 -68.0
 ASP-512   ALA-513  18.1 15.9 39.4 115.2 91.4 72.4 52.6
 ALA-513   CYS-514  19.7 12.1 80.9 -88.4 85.6 124.3 1.1
 CYS-514   GLY-515  22.8 12.2 106.1 147.8 103.8 130.5 36.6
 GLY-515   SER-516  24.5 15.6 35.2 128.7 171.2 61.7 -112.7
 SER-516   ASN-517  25.7 19.3 30.6 -5.2 119.5 93.2 -13.3
 ASN-517   SER-518  23.3 21.0 30.7 177.3 74.6 156.5 165.3
 SER-518   TRP-519  21.5 22.8 -123.5 -37.0 36.4 30.7 -239.1
 TRP-519   ASN-520  19.7 20.8 -16.2 18.4 97.6 88.0 -9.6
 ASN-520   MET-521  22.3 23.7 -4.9 21.2 62.1 65.2 -4.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-554   THR-555  14.2 16.1 -18.7 -68.0 78.0 82.5 22.5
 THR-555   LEU-556  15.9 16.2 -118.2 176.3 128.0 151.3 60.8
 LEU-556   THR-557  17.9 17.4 32.1 -26.6 93.0 80.6 1.6
 THR-557   MET-558  19.5 15.0 -70.8 -93.5 125.4 126.9 -118.3
 MET-558   VAL-559  23.0 17.8 -144.2 158.8 168.4 59.6 -26.1
 VAL-559   GLU-560  21.9 19.9 155.9 -57.7 81.4 111.7 128.4
 GLU-560   ASN-561  18.9 17.4 -113.7 0.8 80.5 104.2 4.1
 ASN-561   ASP-562  15.7 14.1 -177.0 14.7 84.0 44.3 96.2
 ASP-562   HIS-563  17.2 11.1 37.2 92.5 115.2 163.2 -184.0
 HIS-563   ILE-564  14.3 13.3 -120.0 14.0 60.1 73.2 39.0
 ILE-564   ARG-565  12.4 13.2 -14.3 46.4 55.6 77.6 -58.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees