Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-207   ASP-208  1.2 1.0 9.2 8.4 75.6 70.3 38.1
 ASP-208   THR-209  5.0 4.7 -40.3 8.2 63.6 77.9 37.9
 THR-209   LEU-210  6.2 6.0 -9.8 33.2 141.2 132.2 66.8
 LEU-210   GLN-211  7.0 6.4 0.6 13.9 57.4 53.9 2.8
 GLN-211   ALA-212  7.7 7.8 -16.9 18.1 67.3 72.9 -14.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-342   GLN-343  3.1 2.8 -13.5 10.3 32.6 37.5 18.1
 GLN-343   SER-344  1.5 1.8 -8.4 -1.3 84.8 88.7 6.6
 SER-344   PRO-345  2.0 1.9 -17.4 -6.2 8.9 10.9 98.1
 PRO-345   GLU-346  3.1 2.6 13.0 -15.7 108.0 95.9 22.9
 GLU-346   VAL-347  4.9 5.4 9.6 25.1 95.8 98.7 -24.7
 VAL-347   ARG-348  8.5 8.7 33.5 2.2 146.0 162.1 -104.8
 ARG-348   SER-349  9.6 9.7 -17.4 -0.9 94.2 90.0 29.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-474   ALA-475  5.5 5.6 21.9 -4.6 38.8 37.1 45.6
 ALA-475   PRO-476  6.3 6.1 9.1 1.6 66.7 76.3 40.1
 PRO-476   GLY-477  6.5 7.1 -1.3 95.8 135.3 123.1 210.1
 GLY-477   ARG-478  4.1 6.2 -38.9 4.4 104.0 170.4 -93.7
 ARG-478   TYR-479  5.0 5.5 -116.4 45.7 117.9 113.9 -94.3
 TYR-479   ASP-480  5.5 6.0 -9.5 1.1 150.1 153.8 -16.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees