Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-13   ILE-14  8.1 7.6 -5.1 5.8 69.9 72.3 16.4
 ILE-14   THR-15  7.0 6.7 1.0 -0.8 42.6 42.8 1.9
 THR-15   LEU-16  7.3 7.0 0.8 -7.6 112.7 111.5 50.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASN-22   VAL-23  11.2 10.9 0.5 -3.0 70.7 73.6 32.7
 VAL-23   PRO-24  10.6 10.3 -3.0 6.4 85.9 85.1 39.3
 PRO-24   GLU-25  13.0 12.8 -11.1 9.0 148.7 148.7 -49.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-30   TYR-31  7.6 7.5 5.8 -2.7 154.2 155.9 -58.3
 TYR-31   ILE-32  8.9 8.9 -2.0 -0.6 97.3 94.3 -28.1
 ILE-32   GLU-33  11.4 11.3 -4.7 -2.8 20.1 21.6 87.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-57   LYS-58  18.3 18.1 4.8 13.7 98.7 98.1 -76.2
 LYS-58   GLY-59  20.8 21.0 -3.5 -14.1 29.7 36.6 201.5
 GLY-59   GLU-60  20.6 20.4 15.2 -14.2 146.3 156.0 -12.9
 GLU-60   ARG-61  20.2 20.0 7.1 3.8 117.3 115.9 -57.2
 ARG-61   LYS-62  16.5 16.3 -3.2 0.4 104.6 106.4 -28.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-98   ILE-99  3.4 3.4 -1.5 1.3 24.6 23.2 -7.9
 ILE-99   MET-100  5.1 5.1 4.0 -4.1 91.0 93.1 -30.7
 MET-100   GLY-101  8.6 8.6 -4.1 -6.8 22.9 19.3 115.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-102   LEU-103  13.4 13.5 -0.8 4.9 51.6 45.7 -101.3
 LEU-103   THR-104  16.3 16.2 7.7 -11.9 72.4 77.0 29.4
 THR-104   THR-105  19.9 20.0 -11.7 17.3 52.3 37.2 -40.2
 THR-105   PRO-106  21.9 21.5 6.3 -5.4 64.3 81.2 -21.1
 PRO-106   VAL-107  25.7 25.2 12.9 -22.1 76.5 84.5 -86.8
 VAL-107   GLY-108  27.5 28.1 17.7 7.2 107.7 117.5 -174.3
 GLY-108   GLY-109  30.7 31.3 -0.8 77.3 22.6 5.8 -942.9
 GLY-109   GLY-110  30.4 29.7 173.9 -15.0 103.7 112.5 2443.0
 GLY-110   ILE-111  28.4 29.0 -153.8 -47.6 58.8 71.7 -721.8
 ILE-111   ARG-112  25.1 25.2 -8.8 -20.0 118.2 139.1 -340.9
 ARG-112   SER-113  23.2 23.1 8.9 7.9 72.5 69.6 138.4
 SER-113   LEU-114  20.0 20.1 2.2 3.0 131.5 128.8 -43.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-312   LEU-313  16.7 16.7 -0.6 0.0 70.2 67.2 33.1
 LEU-313   ALA-314  14.1 14.0 1.7 -4.4 104.8 102.2 25.3
 ALA-314   ALA-315  11.2 11.2 0.7 -3.0 155.5 150.0 27.3
 ALA-315   GLN-316  12.8 13.0 -4.9 -8.9 41.8 36.2 182.4
 GLN-316   VAL-317  12.3 12.8 -8.7 36.1 79.0 75.5 -250.4
 VAL-317   GLY-318  8.6 9.1 -2.5 -56.1 91.0 81.1 90.2
 GLY-318   GLY-319  8.0 8.6 32.9 158.0 55.0 33.6 1969.1
 GLY-319   ILE-320  10.6 7.7 -156.2 29.7 154.1 130.7 -1728.9
 ILE-320   GLY-321  10.5 10.9 -39.8 -29.6 102.1 128.0 -519.7
 GLY-321   ILE-322  9.0 9.7 15.0 -3.8 87.2 69.1 -20.9
 ILE-322   ALA-323  5.6 6.0 -21.2 47.7 122.9 119.1 136.2
 ALA-323   PRO-324  6.8 6.7 21.9 5.0 14.6 18.6 298.2
 PRO-324   GLY-325  5.0 4.9 -0.4 -1.3 128.3 129.0 107.0
 GLY-325   ALA-326  6.6 6.7 -29.8 11.0 158.1 156.4 -244.2
 ALA-326   ASN-327  6.3 6.3 3.5 -11.1 54.8 55.1 -21.4
 ASN-327   ILE-328  8.4 8.4 -6.5 5.7 133.9 137.2 -30.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-333   LEU-334  4.1 4.3 5.3 -5.2 107.4 110.2 0.7
 LEU-334   PHE-335  4.5 4.7 -3.4 4.0 8.0 6.4 -11.3
 PHE-335   GLU-336  3.9 4.0 2.5 21.2 112.1 111.2 -115.6
 GLU-336   ALA-337  6.7 6.9 -6.0 -0.3 25.7 9.6 104.4
 ALA-337   THR-338  7.8 8.4 -21.0 -39.0 92.5 86.2 -65.4
 THR-338   HIS-339  10.4 10.3 30.9 -15.5 97.0 121.7 -10.0
 HIS-339   GLY-340  12.6 12.8 9.4 18.7 39.7 51.0 245.5
 GLY-340   THR-341  15.4 16.1 -14.2 -1.1 77.6 92.1 -32.8
 THR-341   ALA-342  17.3 17.7 -7.3 15.6 34.0 38.4 -12.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-358   SER-359  1.0 1.0 -7.0 2.3 27.8 29.7 84.8
 SER-359   ALA-360  1.8 1.8 8.7 -7.1 125.9 125.7 -17.7
 ALA-360   GLU-361  2.8 2.7 5.7 -6.1 73.5 77.3 -16.8
 GLU-361   MET-362  3.4 3.4 1.3 1.3 57.1 54.9 41.7
 GLU-361   MET-362  3.4 3.4 1.3 1.3 57.1 54.9 41.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-361   MET-362  3.4 3.4 1.3 1.3 57.1 54.9 41.7
 GLU-361   MET-362  3.4 3.4 1.3 1.3 57.1 54.9 41.7
 MET-362   MET-363  3.3 3.3 0.8 -1.8 20.6 20.4 -34.6
 MET-363   LEU-364  2.6 2.5 -1.7 -1.5 95.9 97.9 10.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees