Cytochrome P450 2D6

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i		 Residue
i+1		 Distance of hinge axis to residue i in conformer 1
(A) 		Distance of hinge axis to residue i in conformer 2
(A) 		Change in psi (i)
(deg) 		Change in phi (i+1)
(deg) 		Angle of psi(i) axis to hinge axis conformer 1
(deg) 		Angle of psi(i) axis to hinge axis conformer 2
(deg) 		Percentage Progress
 VAL-68   PHE-69  6.2 6.4 5.3 -4.8 7.7 9.2 0.4
 PHE-69   SER-70  5.3 5.6 8.1 -1.3 61.7 60.5 20.2
 SER-70   LEU-71  3.2 3.8 -2.5 0.4 126.1 123.3 -19.8
 LEU-71   GLN-72  0.6 0.9 11.1 -1.1 61.4 60.5 59.6
 GLN-72   LEU-73  2.0 1.7 6.9 -0.2 78.8 88.6 5.6
 LEU-73   ALA-74  5.2 5.0 8.9 -9.1 60.3 54.3 7.9
 ALA-74   TRP-75  7.3 7.3 -3.7 -6.4 96.6 107.4 -25.6
 TRP-75   THR-76  8.7 8.2 35.2 -30.6 145.8 143.8 -5.3
 THR-76   PRO-77  7.7 7.4 1.6 2.3 101.8 105.7 -0.8
 PRO-77   VAL-78  5.6 5.5 6.5 -8.0 164.4 166.5 24.7

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Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees

Residue
i		 Residue
i+1		 Distance of hinge axis to residue i in conformer 1
(A) 		Distance of hinge axis to residue i in conformer 2
(A) 		Change in psi (i)
(deg) 		Change in phi (i+1)
(deg) 		Angle of psi(i) axis to hinge axis conformer 1
(deg) 		Angle of psi(i) axis to hinge axis conformer 2
(deg) 		Percentage Progress
 PRO-475   SER-476  30.2 30.5 2.9 -5.4 98.2 98.3 8.7
 SER-476   HIS-477  27.3 27.5 -2.9 -5.9 121.7 117.1 -30.0
 HIS-477   HIS-478  24.0 24.1 11.3 -3.6 131.1 133.2 -54.0
 HIS-478   GLY-479  22.2 22.5 -4.3 -17.2 79.2 72.5 49.7
 GLY-479   VAL-480  20.5 20.5 -36.7 45.8 14.9 16.8 -91.8
 VAL-480   PHE-481  21.0 20.3 9.9 23.9 98.9 94.4 -13.8
 PHE-481   ALA-482  17.8 16.7 12.8 -25.2 129.5 113.4 49.6
 ALA-482   PHE-483  18.3 16.0 123.5 -147.6 72.0 57.9 13.5
 PHE-483   LEU-484  15.0 14.0 28.7 -32.2 4.0 18.4 -32.8
 LEU-484   VAL-485  16.4 16.3 -34.9 9.5 92.9 90.7 19.0
 VAL-485   SER-486  17.2 17.4 7.5 -13.3 47.6 42.4 -14.5
 SER-486   PRO-487  20.8 20.8 2.6 -1.0 81.1 91.8 56.8
 PRO-487   SER-488  23.1 23.2 8.7 -3.3 133.4 128.8 -20.8
 SER-488   PRO-489  25.7 26.1 8.6 -4.7 64.9 58.9 35.1
 PRO-489   TYR-490  28.8 29.3 -2.1 5.8 128.1 126.2 19.8
 TYR-490   GLU-491  30.8 31.0 -7.7 6.6 125.6 128.4 -17.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees