Asp/glu-Specific Dipeptidyl-Peptidase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ILE-293   ASP-294  6.5 5.9 -26.8 11.3 126.1 129.4 -40.3  ASP-294   ASN-295  4.5 4.8 11.3 21.2 22.1 16.4 140.4  ASN-295   ASN-296  5.3 4.8 -16.2 -12.7 98.5 101.2 -20.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LYS-335   ARG-336  6.6 6.6 -5.8 16.8 111.2 112.1 28.1  ARG-336   ALA-337  4.0 4.3 -10.0 10.0 133.7 131.3 -4.1  ALA-337   GLN-338  4.5 4.3 -2.4 7.0 69.5 66.8 4.1 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLU-384   GLY-385  5.8 4.8 -10.0 -18.9 45.5 53.8 70.8  GLY-385   ARG-386  3.6 3.0 14.8 11.8 66.6 70.2 27.5  ARG-386   GLN-387  3.6 3.0 -5.8 8.1 138.5 132.7 5.2 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ALA-540   ALA-541  8.8 9.1 -0.2 7.0 135.0 130.8 6.1  ALA-541   PHE-542  6.9 6.7 -17.5 4.8 73.1 62.5 41.0  PHE-542   ASP-543  4.4 4.3 -24.1 0.2 53.9 48.1 70.0  ASP-543   ALA-544  7.3 7.1 3.1 7.4 65.3 68.4 12.8  ALA-544   PRO-545  9.3 9.5 -6.8 2.5 98.7 95.3 -5.7 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees