Cyclin-Dependent Kinase 5

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-47   ALA-48  13.7 13.8 -1.0 9.4 91.6 82.3 14.9
 ALA-48   LEU-49  10.6 10.8 5.0 -6.1 60.6 58.9 11.7
 LEU-49   ARG-50  9.5 9.2 2.1 4.0 123.3 114.0 -33.6
 ARG-50   GLU-51  10.7 10.5 -6.6 2.7 44.8 39.4 30.2
 GLU-51   ILE-52  8.2 8.4 -1.8 5.5 111.1 108.2 8.3
 ILE-52   CYS-53  5.2 5.2 -3.0 6.5 101.3 104.7 -2.5
 CYS-53   LEU-54  7.3 6.7 -1.8 1.4 37.8 40.3 11.8
 LEU-54   LEU-55  8.3 7.9 1.8 -1.1 117.3 121.9 -19.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASN-62   ILE-63  5.0 4.9 -0.3 1.0 46.5 51.0 23.0
 ILE-63   VAL-64  4.3 4.2 1.3 1.0 108.9 109.2 1.2
 VAL-64   ARG-65  1.6 1.6 -4.7 -5.4 30.5 29.0 77.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-76   THR-77  11.3 11.5 -3.1 3.3 18.7 18.8 9.5
 THR-77   LEU-78  10.5 10.7 -5.6 11.5 68.0 72.6 15.5
 LEU-78   VAL-79  7.6 7.6 2.4 6.6 139.6 136.3 -65.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees