Heavy Chain Of A Vegf Binding Antibody

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  SER-119   SER-120  4.7 3.7 -2.5 5.0 164.2 161.9 8.1  SER-120   ALA-121  5.2 3.6 -8.8 -1.9 91.3 97.5 14.8  ALA-121   SER-122  5.2 2.9 23.1 -29.2 66.4 77.4 4.3  SER-122   THR-123  5.0 3.5 19.8 -13.4 133.0 129.5 -2.5  THR-123   LYS-124  6.3 6.3 9.1 18.2 84.0 84.3 15.2  LYS-124   GLY-125  9.7 9.3 -13.4 5.6 29.9 41.6 14.5  GLY-125   PRO-126  12.3 12.1 -4.2 -7.0 63.4 60.4 20.4  PRO-126   SER-127  13.8 13.8 1.1 -2.2 80.9 81.8 -1.4 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees