Camp And Camp-Inhibited Cgmp 3',5'-Cyclic Phosphodiesterase 10A

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i		 Residue
i+1		 Distance of hinge axis to residue i in conformer 1
(A) 		Distance of hinge axis to residue i in conformer 2
(A) 		Change in psi (i)
(deg) 		Change in phi (i+1)
(deg) 		Angle of psi(i) axis to hinge axis conformer 1
(deg) 		Angle of psi(i) axis to hinge axis conformer 2
(deg) 		Percentage Progress
 LYS-680   LEU-681  20.0 19.9 -2.9 4.9 151.8 144.0 5.1
 LEU-681   TRP-682  19.7 19.1 -1.8 4.1 82.6 73.3 2.2
 TRP-682   PRO-683  16.3 15.4 -3.1 -2.4 60.2 53.2 8.9
 PRO-683   VAL-684  17.5 16.2 -7.4 17.2 6.5 16.9 -18.1
 VAL-684   THR-685  17.9 17.7 5.7 -0.5 107.5 114.6 -11.8
 THR-685   LYS-686  15.1 15.0 -5.0 -2.6 90.7 76.0 -2.7
 LYS-686   LEU-687  12.4 12.3 -4.9 10.9 34.8 34.0 -4.4
 LEU-687   THR-688  13.6 14.2 -13.8 32.7 37.4 35.2 -28.5
 THR-688   ALA-689  13.4 14.2 -102.2 55.0 102.0 77.9 8.7
 ALA-689   ASN-690  9.8 10.5 -6.6 18.3 36.2 56.9 -18.5
 ASN-690   ASP-691  8.2 10.2 -55.1 9.0 49.3 12.3 83.2
 ASP-691   ILE-692  10.6 11.7 5.1 -0.6 99.7 112.7 -8.8
 ILE-692   TYR-693  9.6 10.0 -13.9 12.3 51.0 76.0 8.6
 TYR-693   ALA-694  6.3 6.5 -45.6 -11.4 21.6 41.7 103.3
 ALA-694   GLU-695  8.2 7.9 21.3 1.7 139.9 149.1 -39.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees

Residue
i		 Residue
i+1		 Distance of hinge axis to residue i in conformer 1
(A) 		Distance of hinge axis to residue i in conformer 2
(A) 		Change in psi (i)
(deg) 		Change in phi (i+1)
(deg) 		Angle of psi(i) axis to hinge axis conformer 1
(deg) 		Angle of psi(i) axis to hinge axis conformer 2
(deg) 		Percentage Progress
 ASP-717   LYS-718  6.4 6.4 28.4 -33.6 155.1 141.7 7.5
 LYS-718   LYS-719  4.7 4.7 -70.0 58.6 57.8 53.9 16.6
 LYS-719   ASP-720  3.8 3.0 -28.1 1.7 15.2 16.9 48.7
 ASP-720   GLU-721  3.8 3.7 -0.2 21.3 70.8 80.2 -3.0
 GLU-721   VAL-722  1.2 3.1 -14.8 3.1 101.5 89.9 -0.2
 VAL-722   PRO-723  2.6 1.9 -4.5 0.8 38.0 35.2 3.0
 PRO-723   GLN-724  3.9 3.1 0.3 -5.3 97.7 96.4 -4.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees