Human Cyclin-Dependent Kinase 2

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-30   ALA-31  9.6 9.6 10.3 -18.8 131.1 130.9 26.8
 ALA-31   LEU-32  7.1 7.4 18.5 -9.6 149.3 150.2 -36.8
 LEU-32   LYS-33  8.7 8.4 12.3 -1.3 136.9 137.6 -70.1
 LYS-33   LYS-34  6.3 6.1 1.7 -16.8 153.1 142.0 89.3
 LYS-34   ILE-35  7.7 8.0 3.3 -24.5 122.4 142.3 63.2
 ILE-35   ARG-36  5.2 6.6 -14.8 -132.8 17.1 36.1 860.5
 THR-41   GLU-42  6.7 8.8 -169.2 -37.0 50.9 95.2 -246.0
 GLU-42   GLY-43  9.2 12.1 -9.8 -4.6 116.4 153.3 -80.5
 GLY-43   VAL-44  11.8 12.0 -178.5 -137.6 131.6 134.7 139.0
 VAL-44   PRO-45  10.4 11.5 9.5 -10.9 99.6 97.9 -11.4
 PRO-45   SER-46  11.4 11.9 0.6 3.0 43.3 37.8 20.9
 SER-46   THR-47  14.8 15.0 -12.2 14.7 121.1 118.4 -1.8
 THR-47   ALA-48  14.3 14.0 -12.5 11.3 145.1 141.0 -19.2
 ALA-48   ILE-49  11.2 10.8 -10.6 1.0 132.6 141.2 -62.0
 ILE-49   ARG-50  13.5 13.0 9.6 10.2 55.4 57.2 83.1
 ARG-50   GLU-51  16.0 15.4 -10.3 2.1 128.3 136.3 -40.6
 GLU-51   ILE-52  13.8 13.1 8.7 -3.4 33.0 39.6 38.5
 ILE-52   SER-53  11.9 11.5 10.3 0.1 52.4 54.0 71.2
 SER-53   LEU-54  15.1 15.0 -31.8 22.1 122.6 136.3 -71.3
 LEU-54   LEU-55  16.3 15.4 -5.7 3.1 142.6 134.7 -4.7
 LEU-55   LYS-56  13.2 12.0 -19.3 5.2 136.8 127.0 -72.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-57   LEU-58  16.7 16.0 7.9 29.2 126.3 141.3 -207.9
 LEU-58   ASN-59  15.5 14.1 38.7 -42.4 131.0 145.7 76.1
 ASN-59   HIS-60  13.8 14.0 -36.1 -1.1 47.4 49.4 203.5
 HIS-60   PRO-61  12.9 12.6 -1.7 0.4 61.5 60.3 0.5
 PRO-61   ASN-62  10.3 10.1 -1.5 -0.2 109.5 111.7 -17.2
 ASN-62   ILE-63  9.2 8.9 10.2 -5.7 13.1 15.5 18.1
 ILE-63   VAL-64  8.5 8.0 -1.8 9.6 90.5 81.3 24.5
 VAL-64   LYS-65  5.6 5.1 25.6 -22.1 62.9 76.3 40.9
 LYS-65   LEU-66  8.5 7.8 0.3 0.2 39.7 49.6 26.5
 LEU-66   LEU-67  9.5 9.1 20.1 -21.1 104.9 114.6 -22.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PHE-80   GLU-81  7.0 7.1 7.0 -6.0 25.5 20.7 1.5
 GLU-81   PHE-82  6.9 6.5 -4.5 2.3 92.6 88.3 -28.5
 PHE-82   LEU-83  5.5 5.5 -3.2 13.6 138.3 135.9 28.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PHE-146   GLY-147  8.4 6.5 7.9 -174.0 39.1 10.8 -1027.1
 GLY-147   LEU-148  10.1 7.3 156.3 -27.2 38.4 62.4 597.2
 LEU-148   ALA-149  7.0 8.4 -179.2 -10.7 140.2 134.3 817.7
 ALA-149   ARG-150  8.0 11.1 11.5 -49.3 49.3 29.2 -206.6
 ARG-150   ALA-151  10.8 9.2 174.3 10.6 60.1 98.9 46.0
 ALA-151   PHE-152  9.2 5.5 -175.3 21.6 132.9 85.2 -865.1
 PHE-152   GLY-153  5.9 5.6 -175.9 -57.9 90.7 115.0 720.0
 GLY-153   VAL-154  7.3 4.2 82.5 -26.2 105.5 60.3 -162.1
 VAL-154   PRO-155  7.2 3.1 13.2 11.7 46.3 125.6 79.4
 PRO-155   VAL-156  6.8 2.6 -10.0 -43.7 79.7 70.4 -394.2
 VAL-156   ARG-157  10.2 5.7 146.2 44.0 110.4 97.0 901.1
 ARG-157   THR-158  9.7 8.6 -33.8 -54.8 73.0 47.2 300.9
 THR-158   TYR-159  7.5 10.6 -11.4 -0.5 126.2 78.9 6.0
 TYR-159   THR-160  7.3 13.4 -24.6 48.0 89.2 57.6 -154.7
 THR-160   HIS-161  11.0 11.1 -59.5 -155.8 108.7 120.4 -727.1
 HIS-161   GLU-162  11.7 9.1 -48.4 -13.7 48.6 132.8 -38.4
 GLU-162   VAL-163  12.4 11.7 -160.5 -44.9 103.3 69.0 -326.7
 VAL-163   VAL-164  13.3 14.8 178.5 16.5 139.2 152.8 855.6
 VAL-164   THR-165  11.4 14.2 -172.1 11.7 72.2 89.7 -429.2
 THR-165   LEU-166  14.1 12.6 -179.5 48.0 101.9 101.5 -274.4
 LEU-166   TRP-167  16.4 16.0 -32.2 -4.9 37.7 40.7 180.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees