Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PHE-934   GLY-935  4.6 5.5 89.5 -134.8 126.8 140.9 70.5
 GLY-935   HIS-936  2.7 3.3 41.3 -10.8 87.7 73.9 -12.9
 HIS-936   PHE-937  2.3 1.0 -33.5 7.1 145.6 144.8 -33.9
 PHE-937   LEU-938  5.2 3.9 -3.3 9.0 91.2 88.6 -9.9
 LEU-938   ASP-939  8.3 6.9 -177.8 -80.5 86.7 88.8 13.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-955   LEU-956  5.5 4.0 -15.8 -65.6 67.3 47.0 95.6
 LEU-956   THR-957  6.9 6.0 13.0 -10.8 107.3 96.1 8.9
 THR-957   GLN-958  10.5 9.7 -5.0 -17.2 43.9 27.6 34.5
 GLN-958   ASP-959  13.1 12.4 3.9 -0.6 81.9 92.7 -0.6
 ASP-959   PHE-960  14.5 14.2 1.3 2.9 103.6 112.3 -1.8
 PHE-960   LEU-961  11.5 11.7 1.5 2.9 169.4 173.5 -10.3
 LEU-961   ILE-962  10.7 10.9 5.7 -7.3 122.7 121.1 4.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees