Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  VAL-205   PRO-206  6.0 5.6 2.5 -16.3 54.7 46.7 -48.9  PRO-206   SER-207  4.8 4.8 -6.9 17.4 153.0 138.2 60.1  SER-207   ASP-208  4.1 3.4 9.2 -6.0 95.4 101.2 -6.8  ASP-208   THR-209  3.0 2.9 35.5 -11.6 75.3 74.5 32.5  THR-209   LEU-210  6.4 6.4 15.8 -30.2 153.4 144.6 43.1  LEU-210   GLN-211  7.2 7.1 -15.2 19.9 66.7 74.6 1.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ILE-340   LYS-341  8.0 8.2 31.6 -55.7 74.2 72.5 -8.5  LYS-341   LEU-342  6.0 5.5 -43.2 32.7 81.0 100.5 28.8  LEU-342   GLN-343  2.4 1.8 -4.7 13.5 154.8 164.7 39.9  GLN-343   SER-344  0.1 0.5 3.9 23.0 84.7 80.9 45.9  SER-344   PRO-345  3.5 3.7 -8.6 17.0 135.6 148.3 39.1 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  PRO-476   GLY-477  9.0 8.6 13.5 -72.3 103.2 119.3 63.1  GLY-477   ARG-478  6.3 5.4 75.0 -45.7 150.5 101.9 -94.3  ARG-478   TYR-479  5.2 4.6 62.2 -15.1 88.8 94.1 16.0  TYR-479   ASP-480  4.5 4.3 -11.5 8.7 33.9 37.3 18.9 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees