Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-481   CYS-482  5.4 5.1 -41.5 -3.0 27.8 31.2 231.1
 CYS-482   HIS-483  2.6 2.2 -19.0 11.9 69.4 73.8 -26.0
 HIS-483   ALA-484  4.3 3.3 4.6 -8.3 67.3 68.2 6.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-489   GLY-490  7.0 8.0 18.4 -35.3 83.2 86.8 -32.7
 GLY-490   CYS-491  4.6 5.2 -16.3 13.0 136.6 157.2 -88.5
 CYS-491   TRP-492  4.3 4.8 26.4 7.6 69.8 88.7 165.6
 TRP-492   GLY-493  7.3 7.8 -11.2 -2.1 90.3 89.8 23.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-494   GLU-495  6.9 6.6 -170.0 165.4 45.8 32.1 74.2
 GLU-495   PRO-496  5.9 4.8 -5.8 -6.2 87.1 88.0 -20.1
 PRO-496   ARG-497  3.5 2.1 16.4 -38.0 125.2 126.9 46.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees