Pyruvate Kinase, M2 Isozyme

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-113   LYS-114  7.9 8.1 2.0 -11.3 109.5 103.7 38.6
 LYS-114   GLY-115  5.2 5.0 -13.6 -14.7 68.0 70.5 72.5
 GLY-115   PRO-116  3.2 3.1 19.2 14.4 76.4 90.5 0.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-175   ASP-176  12.0 11.8 15.7 -13.9 80.3 75.9 -17.6
 ASP-176   ASP-177  11.3 11.8 25.5 -4.0 39.5 35.9 110.6
 ASP-177   GLY-178  8.5 9.4 -11.7 6.3 153.0 150.5 -36.5
 GLY-178   LEU-179  9.5 9.3 11.6 -37.6 66.7 58.6 -111.0
 LEU-179   ILE-180  12.9 12.9 14.6 6.7 84.2 95.8 39.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-213   ALA-214  12.6 13.4 -0.7 8.7 56.0 59.3 -22.1
 ALA-214   VAL-215  13.1 12.8 61.3 -60.4 158.6 149.5 -26.9
 VAL-215   ASP-216  11.0 10.5 -4.1 8.4 48.8 51.9 -81.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees