Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-75   LEU-76  5.1 5.6 14.5 -14.7 72.6 75.7 17.0
 LEU-76   MET-77  3.6 4.5 6.4 -4.4 43.9 44.7 0.7
 MET-77   LYS-78  2.2 2.9 -1.3 -15.2 70.4 71.3 24.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-85   ILE-86  6.7 6.9 -4.8 5.2 67.4 65.7 -11.0
 ILE-86   GLY-87  3.4 3.8 21.6 -6.9 52.5 54.5 62.0
 GLY-87   LEU-88  2.7 2.1 3.7 -11.2 94.6 93.8 10.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-109   LEU-110  2.0 1.8 8.7 9.4 44.7 47.7 116.7
 LEU-110   MET-111  0.4 0.2 24.7 -26.8 64.7 72.9 14.4
 MET-111   ASP-112  3.3 3.6 -3.1 9.6 158.8 159.1 34.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-334   PRO-335  9.3 10.0 -8.8 20.6 82.7 87.5 -46.2
 PRO-335   LYS-336  5.7 6.3 -141.6 51.6 143.5 156.6 -451.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees