Receptor Protein-Tyrosine Kinase Erbb-2

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLN-424   GLY-425  5.4 5.1 8.9 1.3 146.6 149.7 -114.3
 GLN-424   GLY-425  15.2 14.8 8.9 1.3 151.4 154.0 -99.0
 GLY-425   LEU-426  14.7 14.4 -8.1 5.9 74.9 74.3 8.4
 GLN-424   GLY-425  5.4 5.1 8.9 1.3 146.6 149.7 -114.3
 GLN-424   GLY-425  15.2 14.8 8.9 1.3 151.4 154.0 -99.0
 GLY-425   LEU-426  14.7 14.4 -8.1 5.9 74.9 74.3 8.4
 LEU-426   GLY-427  12.0 11.4 -28.0 -6.6 50.8 48.5 166.1
 GLY-427   ILE-428  9.1 8.2 44.2 -5.2 59.2 73.4 -125.4
 ILE-428   SER-429  6.7 6.2 9.8 -7.3 92.5 89.9 15.2
 SER-429   TRP-430  3.2 2.7 10.7 -11.2 27.8 27.1 -9.0
 TRP-430   LEU-431  2.5 2.0 -4.5 2.3 127.2 125.1 13.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-450   HIS-451  10.4 10.0 15.8 6.3 81.2 88.9 -12.4
 HIS-451   LEU-452  6.7 6.3 -0.7 10.8 154.2 156.9 89.6
 LEU-452   CYS-453  6.4 6.1 11.9 -24.6 67.8 70.2 -93.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 HIS-456   THR-457  9.7 9.5 -34.1 27.6 66.8 57.4 262.7
 THR-457   VAL-458  7.2 7.2 11.3 7.5 147.8 143.7 -156.5
 VAL-458   PRO-459  5.6 5.4 2.1 -8.8 136.2 133.6 53.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-474   ALA-475  5.7 5.9 0.1 12.9 36.1 34.8 21.7
 THR-474   ALA-475  16.8 16.6 0.1 12.9 143.1 145.0 -24.9
 ALA-475   ASN-476  15.6 15.6 -0.8 -0.2 92.7 85.9 21.6
 THR-474   ALA-475  5.7 5.9 0.1 12.9 36.1 34.8 21.7
 THR-474   ALA-475  16.8 16.6 0.1 12.9 143.1 145.0 -24.9
 ALA-475   ASN-476  15.6 15.6 -0.8 -0.2 92.7 85.9 21.6
 ASN-476   ARG-477  11.9 11.9 13.7 -19.6 119.4 123.0 35.7
 ARG-477   PRO-478  10.1 10.1 1.2 0.9 64.8 56.4 3.7
 PRO-478   GLU-479  12.9 12.8 0.1 10.6 71.2 70.8 -22.7
 GLU-479   ASP-480  12.5 11.9 -2.3 -0.7 61.7 57.7 -12.5
 ASP-480   GLU-481  14.6 14.3 -6.2 9.8 42.0 33.7 -14.2
 GLU-481   CYS-482  11.9 12.0 3.1 -9.5 72.6 76.2 35.5
 CYS-482   VAL-483  9.3 9.2 -3.4 8.0 96.1 99.0 36.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees