Basic Fibroblast Growth Factor Receptor 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  MET-537   ILE-538  9.7 10.4 -14.6 17.0 91.7 89.5 -1.4  ILE-538   GLY-539  6.2 6.9 -8.4 12.3 69.8 72.5 -22.9  GLY-539   LYS-540  8.1 8.9 15.8 -29.6 138.1 146.3 52.3 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ASN-543   ILE-544  5.0 5.2 3.9 -9.8 99.8 101.4 -6.1  ILE-544   ILE-545  1.9 1.9 26.5 -15.0 40.9 43.8 33.1  ILE-545   ASN-546  2.4 2.8 -21.3 1.3 69.9 65.8 62.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLU-562   TYR-563  5.9 5.9 17.9 -13.3 124.3 123.2 7.2  TYR-563   ALA-564  3.9 3.4 38.0 -28.7 91.5 83.1 7.5  ALA-564   SER-565  0.3 0.4 -2.1 -5.4 30.4 26.3 0.2 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LYS-638   ILE-639  2.7 2.9 4.1 -3.0 115.0 111.4 -13.2  ILE-639   ALA-640  3.1 2.9 7.0 9.4 81.2 82.9 14.2  ALA-640   ASP-641  4.5 4.3 -13.6 -2.9 64.5 49.1 42.8  ASP-641   PHE-642  8.1 7.4 -32.2 -1.6 6.9 12.7 218.9  PHE-642   GLY-643  8.2 5.7 -5.6 -43.9 70.5 63.5 51.7  PRO-663   VAL-664  18.3 19.0 -63.5 -12.1 54.5 39.7 300.2  VAL-664   LYS-665  20.9 21.3 0.9 4.4 82.9 88.8 2.1  LYS-665   TRP-666  20.9 21.1 -10.0 9.6 73.7 71.8 5.3 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees