P2x Purinoceptor 7

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LYS-110   SER-111  9.8 9.2 8.4 -4.0 68.8 61.9 12.5  SER-111   GLU-112  8.0 7.8 1.6 -33.4 72.9 76.6 -93.2  GLU-112   GLY-113  5.1 4.9 -143.4 166.8 83.4 113.1 79.4 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ALA-170   GLU-171  14.2 12.2 76.6 26.0 75.5 93.0 -18.2  GLU-171   GLU-172  11.6 11.8 -152.4 -27.3 131.9 109.5 758.6  GLU-172   GLY-173  13.4 15.4 -47.1 -139.6 80.5 119.4 -153.1 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ASN-292   PHE-293  14.2 13.7 2.9 -5.9 101.9 107.2 -9.3  PHE-293   ARG-294  10.5 10.0 11.3 13.1 28.4 31.8 130.6  ARG-294   TYR-295  7.9 7.1 25.9 -19.8 88.8 85.6 -69.0 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ARG-307   THR-308  2.3 2.1 -14.8 8.6 65.0 67.8 34.0  THR-308   LEU-309  2.3 2.2 -11.5 23.5 140.3 149.5 49.0  LEU-309   ILE-310  4.8 4.4 10.7 -11.7 102.1 98.9 20.9 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees