Cyclin Dependent Kinase 2

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-33   LYS-34  11.4 11.5 -6.4 10.5 76.2 75.4 -23.3
 LYS-34   ILE-35  15.2 15.3 -31.0 57.2 75.3 77.5 -72.1
 VAL-44   PRO-45  21.8 22.9 36.2 8.7 89.0 155.7 -116.5
 PRO-45   SER-46  20.7 23.2 2.9 -6.2 141.1 131.9 19.5
 SER-46   THR-47  20.0 21.8 3.5 -4.2 75.6 106.8 -8.5
 THR-47   ALA-48  17.3 20.2 -1.7 -1.9 88.1 126.4 -12.9
 ALA-48   ILE-49  15.4 18.0 16.9 -9.5 163.2 100.7 -26.1
 ILE-49   ARG-50  15.8 17.1 -3.2 -0.1 68.0 44.1 -1.0
 ARG-50   GLU-51  14.4 15.4 -1.3 5.7 111.6 108.5 26.2
 GLU-51   ILE-52  11.5 14.1 0.9 -23.1 116.9 56.7 19.4
 ILE-52   SER-53  10.6 12.0 36.5 -10.6 154.0 119.6 -105.2
 SER-53   LEU-54  10.3 11.4 -6.7 4.3 92.5 61.4 2.0
 LEU-54   LEU-55  8.8 9.4 22.1 -1.2 75.4 52.2 59.3
 LEU-55   LYS-56  5.8 7.5 4.5 -7.1 133.9 85.8 17.9
 LYS-56   GLU-57  5.8 6.2 4.7 15.8 125.9 129.0 -62.2
 GLU-57   LEU-58  3.9 4.0 -3.4 11.0 120.1 107.6 37.2
 LEU-58   ASN-59  3.1 3.4 2.7 -0.4 69.4 49.2 -25.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-63   VAL-64  3.9 3.9 4.4 -12.2 109.5 111.9 25.9
 VAL-64   LYS-65  0.7 1.1 -8.2 26.9 139.8 133.1 60.2
 LYS-65   LEU-66  2.1 2.1 -1.7 -12.5 80.6 77.3 0.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PHE-82   LEU-83  5.2 4.6 5.9 -0.6 71.0 76.1 1.3
 LEU-83   HIS-84  3.4 2.8 3.5 -10.2 11.3 7.4 -35.2
 HIS-84   GLN-85  3.9 3.5 23.6 2.4 61.4 57.6 63.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees