Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-481   CYS-482  12.4 11.8 -9.8 -19.0 32.0 18.4 130.7
 CYS-482   HIS-483  10.7 10.7 20.4 -10.9 92.8 95.2 7.1
 HIS-483   ALA-484  7.9 7.5 0.7 -15.9 84.5 83.4 23.0
 ALA-484   LEU-485  4.2 4.6 9.6 2.8 35.0 30.8 38.6
 ALA-484   LEU-485  4.2 4.6 9.6 2.8 35.0 30.8 38.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-484   LEU-485  4.2 4.6 9.6 2.8 35.0 30.8 38.6
 ALA-484   LEU-485  4.2 4.6 9.6 2.8 35.0 30.8 38.6
 LEU-485   CYS-486  3.7 4.0 18.2 -29.4 72.4 68.0 -46.7
 CYS-486   SER-487  7.3 7.8 6.5 0.6 115.1 114.1 37.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-494   GLU-495  13.4 13.7 -157.3 150.8 48.1 32.4 72.6
 GLU-495   PRO-496  11.8 11.0 7.1 -15.2 110.6 113.3 13.8
 PRO-496   ARG-497  8.5 8.1 11.2 -17.3 145.5 146.2 22.1
 ARG-497   ASP-498  10.4 10.5 16.0 -40.1 73.5 79.7 -39.6
 ASP-498   CYS-499  12.8 13.2 49.9 -40.8 77.7 67.0 -9.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ARG-503   ASN-504  6.6 8.0 -18.9 8.8 58.4 60.5 27.7
 ASN-504   VAL-505  5.1 6.3 -4.4 7.6 11.9 10.0 2.1
 VAL-505   SER-506  3.8 4.9 4.7 -1.8 102.2 99.4 -11.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ARG-509   GLU-510  9.1 9.4 -1.3 5.6 25.6 27.7 -22.8
 GLU-510   CYS-511  7.1 7.0 -17.1 9.6 68.0 75.6 17.5
 CYS-511   VAL-512  4.7 5.0 -3.6 6.9 74.6 71.8 33.0
 VAL-512   ASP-513  1.6 1.2 13.3 10.4 113.9 110.5 -32.4
 ASP-513   LYS-514  2.0 2.4 -11.6 -10.8 127.5 133.1 -48.6
 LYS-514   CYS-515  4.3 4.5 3.6 2.8 28.4 32.2 43.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-524   PHE-525  5.7 5.4 12.6 -16.1 98.8 95.1 7.6
 PHE-525   VAL-526  6.7 7.0 -21.7 17.7 62.9 62.4 -6.0
 VAL-526   GLU-527  6.7 7.3 -18.7 49.3 113.7 117.5 34.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-530   CYS-531  4.8 6.1 -19.2 18.1 69.1 62.0 23.8
 CYS-531   ILE-532  1.9 2.9 16.0 -17.5 154.9 152.0 9.6
 ILE-532   GLN-533  1.7 2.1 6.0 -5.7 110.1 106.6 29.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees