Cetuximab Fab Heavy Chain
(All numbering and residues are taken from first PDB file)
Bending Residue Dihedral Analysis
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
LYS-5
GLN-6
22.5
22.3
-5.5
3.4
158.2
158.0
-21.3
GLN-6
SER-7
20.0
19.8
13.3
68.1
61.7
60.1
410.1
SER-7
GLY-8
19.4
18.9
14.8
136.0
41.7
103.9
-736.3
GLY-8
PRO-9
16.8
16.0
31.7
-12.7
82.9
71.6
31.2
PRO-9
GLY-10
14.0
12.1
38.4
-91.7
104.5
27.5
869.5
GLY-10
LEU-11
10.9
10.4
-164.4
-10.2
115.4
116.3
-638.1
LEU-11
VAL-12
7.9
7.6
10.6
7.9
28.5
39.0
68.9
VAL-12
GLN-13
7.6
7.8
13.2
-15.2
57.7
62.7
39.7
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
VAL-117
SER-118
4.8
5.2
10.7
-6.7
70.2
76.9
2.0
SER-118
ALA-119
1.5
1.8
-6.0
19.0
148.5
152.7
84.8
ALA-119
ALA-120
0.9
0.7
-17.5
10.6
86.5
86.4
15.0
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees