Cystic Fibrosis Transmembrane Conductance Regulator
(All numbering and residues are taken from first PDB file)
Bending Residue Dihedral Analysis
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
CYS-226
ALA-227
10.5
11.1
4.6
-5.0
16.1
23.5
-19.3
ALA-227
LEU-228
9.6
10.1
14.9
-4.1
49.5
49.7
58.4
LEU-228
ALA-229
12.8
13.3
-10.2
-2.6
86.1
80.6
29.2
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
VAL-324
PRO-325
4.2
5.4
22.5
-7.4
39.0
29.2
79.8
PRO-325
HIS-326
5.9
6.4
1.4
0.8
78.4
78.5
31.4
HIS-326
ALA-327
9.1
9.9
-2.9
4.6
118.1
106.4
3.8
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
THR-846
TYR-847
15.7
16.0
16.6
-0.5
159.9
176.1
-69.4
TYR-847
VAL-848
15.7
15.4
-5.3
8.1
83.6
79.5
13.6
VAL-848
ARG-849
18.7
18.4
-0.5
0.9
98.3
88.5
2.3
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
LEU-881
ILE-882
20.0
21.7
0.2
9.0
58.6
38.6
40.8
ILE-882
THR-883
18.0
19.0
-4.0
21.6
71.5
101.0
-110.3
THR-883
ASP-884
20.1
19.5
-14.1
15.3
107.5
132.9
-0.1
ASP-884
GLU-885
23.4
22.8
2.0
-3.0
23.5
15.4
3.6
GLU-885
LEU-886
22.7
21.2
22.1
18.2
93.5
74.7
51.2
THR-918
SER-919
24.5
13.9
-132.1
21.2
110.4
34.5
-457.6
SER-919
SER-920
21.8
11.7
-103.1
-173.4
100.5
43.0
-292.0
SER-920
TYR-921
19.3
14.5
-164.7
-15.4
49.4
32.1
762.2
TYR-921
TYR-922
16.9
13.7
70.3
-9.1
69.9
124.1
-81.2
TYR-922
ILE-923
14.4
11.7
-16.8
6.3
96.6
62.8
26.8
ILE-923
LEU-924
12.3
8.3
-0.2
-4.6
25.1
32.2
36.2
LEU-924
TYR-925
12.0
10.2
-14.5
9.1
76.8
43.9
46.5
TYR-925
ILE-926
10.4
11.4
20.1
-5.4
67.5
113.0
-39.8
ILE-926
TYR-927
7.6
8.1
-9.8
-2.0
59.0
43.2
22.1
TYR-927
VAL-928
7.4
6.9
22.0
-2.0
144.4
146.1
-111.0
VAL-928
ALA-929
6.5
9.8
0.1
-2.2
76.4
131.0
51.7
ALA-929
THR-930
4.8
8.8
-0.1
14.2
106.5
60.6
6.2
THR-930
SER-931
2.6
5.0
81.5
-13.2
129.8
130.2
-259.2
SER-931
GLU-932
3.9
5.8
14.3
-8.9
105.9
112.2
2.5
GLU-932
SER-933
2.6
2.3
-10.3
-6.1
125.8
127.9
-47.3
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
LEU-934
LEU-935
6.9
6.4
-19.8
9.3
142.7
123.9
-10.9
LEU-935
ALA-936
7.8
7.8
-6.4
6.4
104.0
102.6
-7.0
ALA-936
MET-937
8.4
7.1
-6.6
-2.4
95.2
79.2
18.3
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
ASP-1001
PHE-1002
9.8
8.1
-13.1
-0.5
57.3
56.6
34.8
PHE-1002
VAL-1003
7.9
7.0
6.8
-3.9
72.0
72.4
-4.1
VAL-1003
GLN-1004
9.1
9.0
-2.5
-11.7
146.4
144.1
-46.6
GLN-1004
LEU-1005
7.5
7.2
3.0
-0.6
80.2
83.2
5.8
GLN-1004
LEU-1005
7.5
7.2
3.0
-0.6
80.2
83.2
5.8
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
GLN-1004
LEU-1005
7.5
7.2
3.0
-0.6
80.2
83.2
5.8
GLN-1004
LEU-1005
7.5
7.2
3.0
-0.6
80.2
83.2
5.8
LEU-1005
THR-1006
4.0
3.6
-7.1
12.0
118.5
114.4
17.0
THR-1006
VAL-1007
5.0
5.2
6.9
-1.3
130.2
129.3
-10.8
VAL-1007
VAL-1008
7.5
7.7
4.7
-3.4
48.5
51.6
7.9
VAL-1007
VAL-1008
7.5
7.7
4.7
-3.4
48.5
51.6
7.9
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
VAL-1007
VAL-1008
7.5
7.7
4.7
-3.4
48.5
51.6
7.9
VAL-1007
VAL-1008
7.5
7.7
4.7
-3.4
48.5
51.6
7.9
VAL-1008
VAL-1009
4.7
5.1
4.1
0.5
112.8
115.9
-5.6
VAL-1009
VAL-1010
4.2
5.6
2.2
-0.4
109.1
102.5
-0.4
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
ALA-1126
VAL-1127
23.3
22.7
-142.1
83.1
65.6
48.1
248.6
VAL-1127
GLY-1128
26.7
25.2
172.7
-21.9
105.0
72.5
-33.6
GLY-1128
THR-1129
29.7
28.0
-66.8
-32.6
131.6
103.7
-404.8
THR-1129
ASN-1130
32.4
27.7
-140.7
1.0
51.1
64.8
419.0
ASN-1130
GLN-1131
34.3
30.5
-95.2
-95.4
54.7
37.0
-984.6
GLN-1131
ASP-1132
33.9
29.2
18.8
6.1
118.9
134.2
1586.4
ASP-1132
LYS-1133
30.3
30.7
-125.8
-7.7
36.7
56.6
-843.9
LYS-1133
PRO-1134
31.3
27.4
135.5
-22.7
124.5
59.1
45.0
PRO-1134
GLY-1135
27.8
25.2
43.5
-135.3
53.9
114.7
364.0
GLY-1135
GLU-1136
26.9
22.3
120.2
-129.8
87.9
58.6
43.9
GLU-1136
ILE-1137
23.8
20.4
-51.0
-5.1
129.7
127.5
-295.3
ILE-1137
GLY-1138
22.3
20.2
-22.5
-5.4
101.8
70.2
-64.2
GLY-1138
ILE-1139
20.9
17.8
-0.4
-14.9
66.8
108.5
37.2
ILE-1139
ILE-1140
18.0
15.0
-24.0
21.8
134.6
164.2
60.9
ILE-1140
ILE-1141
17.1
16.0
-16.7
-16.3
126.7
109.7
-101.9
ILE-1141
CYS-1142
17.2
16.1
3.4
-2.6
116.4
108.8
-33.6
CYS-1142
LEU-1143
14.9
13.3
-3.5
-5.0
96.8
115.0
37.5
LEU-1143
ALA-1144
12.4
10.7
22.4
-14.1
26.3
11.9
28.3
ALA-1144
MET-1145
12.1
11.6
-5.9
-0.3
93.9
95.9
-12.1
MET-1145
LEU-1146
12.4
11.8
8.6
9.6
104.3
92.7
-18.1
LEU-1146
ILE-1147
9.2
8.3
31.7
-14.2
60.5
39.4
68.1
ILE-1147
LEU-1148
6.8
6.7
7.7
42.8
23.9
47.8
248.8
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees