Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  VAL-204   VAL-205  10.5 10.6 -18.9 29.0 110.3 112.8 6.5  VAL-205   PRO-206  6.7 6.9 -7.3 11.9 50.4 59.0 3.3  PRO-206   SER-207  4.5 4.3 0.7 -11.1 126.0 136.1 34.6  SER-207   ASP-208  2.2 2.4 -20.5 19.8 113.6 107.8 8.8  ASP-208   THR-209  1.9 1.6 -25.8 1.6 78.9 80.1 14.0  THR-209   LEU-210  4.9 4.5 2.3 8.5 27.1 29.4 19.8  LEU-210   GLN-211  5.3 5.1 16.4 -2.5 63.4 57.0 38.8  GLN-211   ALA-212  4.7 5.0 -2.4 3.9 71.1 74.7 2.4 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LEU-342   GLN-343  3.0 2.7 6.2 -9.1 152.5 154.5 9.1  GLN-343   SER-344  3.1 3.0 31.4 14.6 88.7 85.0 8.1  SER-344   PRO-345  6.8 6.7 -25.8 -3.5 28.1 29.3 84.2  PRO-345   GLU-346  8.1 8.0 -11.8 -1.9 94.3 84.5 1.0  GLU-346   VAL-347  11.0 11.1 12.5 -40.6 107.5 93.9 0.1 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ASP-474   ALA-475  9.0 9.2 1.1 12.5 28.4 20.5 52.4  ALA-475   PRO-476  9.5 9.2 9.7 -2.3 56.1 60.4 -0.6  PRO-476   GLY-477  8.7 8.6 9.9 46.3 51.8 68.7 71.4  GLY-477   ARG-478  5.7 5.2 -46.8 30.0 112.9 160.0 -41.6  ARG-478   TYR-479  3.5 4.0 -58.6 5.3 103.0 98.2 -13.6  TYR-479   ASP-480  1.6 1.7 -0.6 18.4 155.7 152.5 46.5 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees