Basic Fibroblast Growth Factor Receptor 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  TYR-563   ALA-564  8.7 8.3 12.6 -16.6 105.2 107.0 3.7  ALA-564   SER-565  5.0 4.7 0.2 -1.7 173.4 167.4 2.0  SER-565   LYS-566  5.1 5.0 -18.3 20.4 61.0 58.5 6.3  LYS-566   GLY-567  1.6 1.4 2.9 -7.1 80.2 78.1 0.4  GLY-567   ASN-568  4.3 4.3 -0.1 10.2 134.5 133.9 35.9 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  TYR-572   LEU-573  5.4 5.2 6.0 -8.7 72.2 71.8 11.3  LEU-573   GLN-574  9.0 8.8 0.9 -1.8 26.4 32.6 -11.9  GLN-574   ALA-575  10.2 10.2 6.1 -7.4 37.9 32.7 -0.9  ALA-575   ARG-576  7.3 7.2 -30.3 23.1 93.3 104.2 -19.2  ARG-576   ARG-577  9.1 8.1 1.2 1.0 76.5 81.1 44.4  ARG-577   PRO-578  12.4 11.6 -35.2 5.6 150.4 158.4 -187.0  PRO-578   PRO-579  14.5 13.1 -32.0 8.5 142.0 120.9 -70.3  GLY-580   LEU-581  18.5 12.4 -19.9 -16.9 134.8 5.1 144.0  LEU-581   GLU-582  21.0 11.8 -65.5 -127.9 153.1 66.7 -786.6  GLU-582   PHE-583  20.4 15.3 -177.8 56.5 95.9 25.0 306.6  PHE-583   SER-584  16.9 17.2 163.1 77.6 107.4 138.8 371.7  SER-584   PHE-585  13.6 16.3 174.9 14.3 98.5 97.0 -142.2  LEU-600   VAL-601  13.3 12.9 5.8 -4.2 172.1 167.3 -1.9  VAL-601   SER-602  14.8 14.6 -2.6 -1.0 63.4 59.4 5.0  SER-602   CYS-603  12.2 11.9 -8.3 10.7 81.9 79.6 -11.5  CYS-603   ALA-604  9.4 9.2 -16.9 17.4 40.0 36.0 -20.1  ALA-604   TYR-605  11.5 11.6 -10.8 2.5 29.4 28.9 54.1  TYR-605   GLN-606  11.4 11.5 4.5 -4.1 106.8 108.3 -2.4  GLN-606   VAL-607  7.8 7.8 -7.8 11.8 67.7 66.1 -13.3  VAL-607   ALA-608  7.1 7.2 -4.3 -1.0 22.5 22.3 29.3 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees