Glucokinase Isoform 2

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-61   VAL-62  12.6 11.0 -25.1 16.8 139.5 150.7 -7.3
 VAL-62   ARG-63  10.4 9.3 72.6 -36.2 41.4 55.4 20.3
 ARG-63   SER-64  13.6 11.9 -20.3 106.8 149.4 171.9 85.6
 SER-64   THR-65  14.4 12.8 26.5 110.0 78.8 65.2 -163.2
 THR-65   PRO-66  17.8 10.2 -84.2 -28.4 124.5 92.2 76.2
 PRO-66   GLU-67  19.9 11.7 82.2 46.2 114.1 66.6 -24.1
 GLU-67   GLY-68  19.6 10.5 166.5 -3.0 68.3 116.6 -36.6
 GLY-68   SER-69  16.4 10.5 100.7 -51.2 109.5 119.9 -18.9
 SER-69   GLU-70  13.8 7.7 3.6 32.6 52.3 92.3 29.6
 GLU-70   VAL-71  11.0 9.2 -33.0 -22.7 59.1 104.6 2.3
 VAL-71   GLY-72  9.0 8.9 -135.9 -174.8 83.8 51.5 -13.8
 GLY-72   ASP-73  5.5 10.5 -147.5 -51.0 48.0 68.0 174.7
 ASP-73   PHE-74  7.0 10.7 -17.2 60.1 35.0 26.2 -34.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLY-92   GLU-93  10.1 7.0 14.7 -18.1 151.8 115.0 1.8
 GLU-93   GLY-94  11.0 6.0 160.7 155.6 135.5 154.4 38.2
 GLY-94   GLU-95  11.0 3.4 31.7 -27.5 138.2 119.4 0.4
 GLU-95   GLU-96  13.2 3.0 -52.4 72.7 45.2 117.1 3.4
 GLU-96   GLY-97  11.6 3.2 -24.1 80.6 116.1 149.9 52.6
 GLY-97   GLN-98  11.9 3.3 -157.9 -22.6 97.1 107.5 27.7
 GLN-98   TRP-99  8.2 2.1 -106.3 70.0 158.8 83.6 -19.1
 TRP-99   SER-100  6.8 3.4 40.4 -18.0 71.6 28.9 15.4
 SER-100   VAL-101  6.2 5.7 -10.2 -19.3 171.6 83.8 -23.1
 VAL-101   LYS-102  5.5 9.4 51.5 -6.9 73.3 35.3 32.5
 LYS-102   THR-103  8.5 11.9 -24.1 24.1 155.0 72.5 -5.1
 THR-103   LYS-104  8.7 14.6 176.5 1.1 69.5 49.5 -152.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 MET-197   ASP-198  15.8 10.6 151.7 -52.5 131.2 82.1 -89.5
 ASP-198   VAL-199  13.5 8.7 151.5 63.2 111.2 106.2 -90.9
 VAL-199   VAL-200  9.9 4.9 -83.9 72.3 111.3 65.3 -14.5
 VAL-200   ALA-201  8.9 4.8 -153.1 -105.7 83.7 84.4 53.6
 ALA-201   MET-202  6.0 2.0 1.3 27.5 134.7 69.2 60.0
 MET-202   VAL-203  5.5 2.6 18.6 -2.5 84.2 116.3 -17.9
 VAL-203   ASN-204  5.5 5.8 179.8 -29.6 110.4 78.1 -3.6
 ASN-204   ASP-205  9.0 9.4 27.6 0.4 145.3 144.7 -15.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees