Insulin-Like Growth Factor 1 Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  TYR-662   CYS-663  24.4 22.0 -5.9 21.3 61.3 58.6 -16.6  CYS-663   SER-664  27.0 24.4 16.4 -54.6 104.5 95.9 4.5  SER-664   LYS-665  26.5 24.5 112.7 -96.9 24.8 35.6 25.7  LYS-665   ASP-666  26.3 24.8 51.0 -84.7 80.5 49.0 -20.7  ASP-666   LYS-667  29.8 26.8 -145.3 -22.7 145.3 157.8 -155.0  LYS-667   ILE-668  28.9 27.2 58.2 -64.6 87.5 74.6 -5.4  ILE-668   PRO-669  26.1 30.1 8.0 -40.8 22.0 27.9 -23.6  PRO-669   ILE-670  23.9 32.4 20.5 -43.4 69.6 61.9 2.1  ILE-670   ARG-671  25.1 33.3 25.3 -22.6 29.0 13.5 1.2 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  TYR-776   PRO-777  8.3 12.0 4.4 3.9 151.8 147.8 -8.3  PRO-777   PHE-778  9.6 14.2 -14.6 8.1 44.7 33.1 10.5  PHE-778   PHE-779  10.7 14.1 -16.7 -0.7 76.2 69.9 2.0 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees