Beta-Secretase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-62   LEU-63  9.9 9.9 -6.5 7.0 42.1 40.5 3.4
 LEU-63   ARG-64  7.3 7.3 -6.6 4.9 68.1 69.2 5.1
 ARG-64   LYS-65  5.6 5.5 -5.5 4.2 87.8 85.7 4.4
 LYS-65   GLY-66  2.0 1.9 -7.6 12.0 160.4 158.6 33.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-77   GLY-78  3.0 3.2 -7.6 10.2 94.1 90.5 -22.7
 GLY-78   GLU-79  1.2 0.9 -12.1 1.8 160.3 159.6 -79.3
 GLU-79   LEU-80  3.2 3.2 -3.1 0.2 95.8 97.1 13.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-104   SER-105  4.9 4.9 4.3 -4.9 68.7 68.6 6.8
 SER-105   ASP-106  4.5 4.5 5.7 -11.3 47.1 50.3 -39.0
 ASP-106   LYS-107  7.2 7.3 3.0 -0.1 59.2 60.3 14.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-113   ASN-114  5.9 6.0 16.2 -12.9 81.2 77.7 19.0
 ASN-114   TRP-115  7.0 7.5 19.3 -21.5 24.6 22.8 -14.3
 TRP-115   GLU-116  7.8 7.8 -2.7 -3.1 126.1 128.6 -23.2
 GLU-116   GLY-117  6.6 6.5 -1.8 4.6 162.5 159.2 27.7
 GLY-117   ILE-118  7.3 7.3 -1.3 -0.1 86.6 86.0 3.8
 ILE-118   LEU-119  9.3 9.3 0.4 -0.9 43.9 43.3 5.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees