Multidrug Resistance Protein 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASN-81   ALA-82  16.2 16.2 8.4 -10.8 51.7 66.6 -53.2
 ALA-82   GLY-83  18.3 17.3 3.9 -3.0 74.1 87.1 -0.4
 GLY-83   ASN-84  16.1 14.1 16.6 -18.1 136.7 150.8 21.4
 PHE-104   MET-105  22.2 23.6 -97.8 4.9 140.3 86.1 -149.9
 MET-105   ASN-106  24.7 26.2 -22.6 11.4 86.0 67.9 38.2
 ASN-106   LEU-107  24.6 23.8 -25.3 -16.4 110.9 136.0 -124.4
 LEU-107   GLU-108  21.0 21.4 23.9 -17.0 40.8 47.4 26.8
 GLU-108   GLU-109  22.1 24.4 -1.0 -12.5 75.6 75.2 28.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-110   MET-111  23.2 22.9 -14.6 5.2 53.4 33.2 20.9
 MET-111   THR-112  20.7 21.0 -2.9 -14.3 50.1 51.6 55.9
 THR-112   ARG-113  23.7 24.3 17.7 -16.2 61.5 67.5 -10.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-213   LEU-214  15.2 16.0 37.0 -34.9 41.0 42.4 -14.2
 LEU-214   THR-215  13.8 15.2 3.1 15.4 63.0 64.4 24.1
 THR-215   LEU-216  17.3 18.8 -25.1 -1.1 55.8 64.3 15.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLY-317   THR-318  6.6 8.4 -1.6 3.4 101.3 103.3 22.2
 THR-318   THR-319  2.9 4.6 -0.3 -5.6 173.8 172.6 -13.1
 THR-319   LEU-320  3.3 4.9 21.6 -26.9 74.9 63.4 -8.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TRP-698   ARG-699  25.9 27.1 -78.2 51.8 80.4 78.9 73.1
 ARG-699   ILE-700  29.4 30.9 -54.5 24.6 42.5 35.0 145.7
 ILE-700   MET-701  30.3 31.6 -30.2 32.9 36.4 40.7 -5.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-744   PRO-745  10.9 12.6 -50.1 -20.6 97.0 99.6 -2.9
 PRO-745   GLU-746  7.4 9.1 38.9 -7.4 103.3 60.8 22.0
 GLU-746   THR-747  8.2 9.0 -1.7 -11.0 14.6 54.4 20.0
 THR-747   LYS-748  8.8 9.0 23.0 0.8 110.7 116.1 -39.7
 LYS-748   ARG-749  5.3 5.7 -9.5 6.3 107.9 111.4 39.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLN-750   ASN-751  7.4 6.6 20.8 -12.6 17.7 15.7 39.9
 ASN-751   SER-752  6.2 6.3 -7.4 11.4 95.1 107.0 -16.8
 SER-752   ASN-753  3.3 3.4 6.1 -4.0 102.1 102.9 -2.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-849   SER-850  3.6 4.8 -6.7 9.4 91.3 88.6 -0.1
 SER-850   PHE-851  2.3 2.6 -13.4 -3.1 50.6 50.0 35.4
 PHE-851   ILE-852  4.5 4.8 7.4 -13.3 63.5 70.5 -22.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-853   GLY-854  6.9 7.4 -58.2 94.8 103.9 105.8 83.1
 GLY-854   TRP-855  8.2 8.4 9.5 -1.7 29.8 17.3 13.2
 TRP-855   GLN-856  8.3 10.8 170.5 121.2 77.9 74.4 -47.4
 GLN-856   LEU-857  11.2 11.4 38.9 -14.3 74.4 63.5 53.7
 GLN-856   LEU-857  11.2 11.4 38.9 -14.3 74.4 63.5 53.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLN-856   LEU-857  11.2 11.4 38.9 -14.3 74.4 63.5 53.7
 GLN-856   LEU-857  11.2 11.4 38.9 -14.3 74.4 63.5 53.7
 LEU-857   THR-858  9.9 9.5 -19.9 4.1 60.7 66.4 31.2
 THR-858   LEU-859  6.6 6.1 -3.6 3.3 25.2 19.6 -3.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PHE-959   GLY-960  16.0 15.8 0.1 -1.6 124.2 130.9 9.0
 GLY-960   ALA-961  13.5 13.4 11.7 -35.2 132.6 133.2 83.8
 ALA-961   TYR-962  16.4 16.6 -124.5 116.5 117.3 131.8 12.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-968   MET-969  15.9 17.3 56.7 61.0 73.9 93.5 89.6
 MET-969   SER-970  12.7 13.7 -33.2 1.6 155.1 143.8 -133.6
 SER-970   PHE-971  11.3 11.6 -23.8 5.3 93.7 81.5 7.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-975   LEU-976  6.2 5.6 -2.1 5.4 117.5 113.4 9.0
 LEU-976   VAL-977  2.7 2.1 -12.4 7.7 161.6 160.0 -19.3
 VAL-977   PHE-978  4.2 3.2 12.1 -5.2 88.1 86.2 14.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees