Acid-Sensing Ion Channel 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-66   GLN-67  18.2 18.4 18.0 -18.0 143.2 154.0 -8.1
 GLN-67   TYR-68  17.2 17.4 -6.5 9.0 98.9 101.4 26.9
 TYR-68   TYR-69  14.2 14.5 5.7 -1.7 87.3 85.2 17.8
 TYR-69   PHE-70  13.1 13.2 -6.0 -6.4 20.0 25.5 63.5
 PHE-70   LEU-71  13.9 13.4 4.6 6.6 118.5 121.8 -53.7
 LEU-71   TYR-72  11.1 11.1 2.2 -0.2 70.2 74.2 -41.0
 TYR-72   PRO-73  8.9 8.6 -8.3 -9.5 100.7 107.0 3.0
 PRO-73   HIS-74  7.0 7.2 4.5 -12.6 67.4 51.0 -40.2
 HIS-74   VAL-75  3.4 4.0 7.2 -4.1 58.6 68.4 41.1
 VAL-75   THR-76  3.1 4.6 29.1 -10.3 96.7 87.5 20.6
 THR-76   LYS-77  3.9 5.3 20.9 -19.3 31.7 22.8 -19.5
 LYS-77   LEU-78  5.0 5.9 -34.1 11.9 86.3 81.0 13.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-416   GLU-417  18.2 18.2 13.1 -2.6 88.5 85.3 19.7
 GLU-417   THR-418  15.1 15.1 -12.4 15.0 119.4 114.3 40.7
 THR-418   ILE-419  11.7 11.6 -5.8 8.3 108.1 110.6 12.3
 ILE-419   GLU-420  9.1 9.3 -21.8 24.4 111.4 107.3 26.3
 GLU-420   GLN-421  6.2 6.1 3.1 -4.3 83.7 83.5 27.7
 GLN-421   LYS-422  2.8 2.7 -4.3 10.9 60.1 58.0 -53.6
 LYS-422   LYS-423  2.5 0.6 -15.6 14.9 105.7 107.5 -44.5
 LYS-423   ALA-424  4.7 4.0 11.7 -17.3 137.3 127.5 28.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees