Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 CYS-79   VAL-80  2.6 2.9 21.4 -21.1 67.7 78.7 -48.5
 VAL-80   ASN-81  1.7 1.4 5.4 17.3 44.3 43.1 152.7
 ASN-81   HIS-82  2.6 2.7 -13.7 9.4 94.7 90.4 47.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-85   ILE-86  6.5 6.7 -2.4 -13.0 54.0 48.9 48.8
 ILE-86   GLY-87  4.5 4.9 14.0 1.1 64.9 64.2 42.6
 GLY-87   LEU-88  0.8 1.4 28.8 -30.1 106.5 110.1 24.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-109   LEU-110  1.4 1.0 -9.6 36.3 128.3 119.4 168.4
 LEU-110   MET-111  3.4 3.3 5.5 -4.2 76.3 91.3 21.0
 MET-111   ASP-112  6.1 6.3 -25.5 14.1 151.7 143.9 -44.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-333   PRO-334  8.4 7.8 0.3 -11.4 104.4 101.7 -21.6
 PRO-334   PRO-335  5.2 5.3 -16.2 20.2 69.4 68.8 21.3
 PRO-335   LYS-336  1.7 2.1 -168.2 80.9 130.5 144.7 -484.7
 GLU-350   GLU-351  26.6 27.2 -30.2 1.0 102.8 118.7 -65.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees