Map Kinase P38

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 HIS-77   MET-78  8.7 7.1 -18.8 9.7 142.0 135.4 -19.2
 MET-78   LYS-79  8.2 7.8 42.0 -20.9 26.4 22.2 49.6
 LYS-79   HIS-80  10.0 9.0 17.2 0.1 60.0 59.4 17.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-84   GLY-85  4.8 4.8 11.7 -3.1 65.0 66.1 9.7
 GLY-85   LEU-86  3.9 2.2 -9.6 7.4 92.6 90.1 -2.4
 LEU-86   LEU-87  3.9 2.3 18.1 -25.7 134.8 133.2 23.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 HIS-107   LEU-108  1.7 2.7 4.7 0.2 91.7 80.5 -15.4
 LEU-108   MET-109  5.0 5.9 5.0 -13.5 74.3 69.6 -16.0
 MET-109   GLY-110  6.6 7.0 -104.6 178.4 119.8 119.7 136.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-168   PHE-169  8.3 9.0 14.4 -36.6 44.4 39.0 -73.7
 PHE-169   GLY-170  8.4 7.3 -123.4 22.7 139.6 144.9 -235.0
 GLY-170   LEU-171  10.2 8.3 -53.0 -25.5 146.0 145.7 -205.9
 LEU-171   ALA-172  7.4 10.2 -118.1 172.3 108.3 98.1 61.9
 ALA-172   ARG-173  6.8 8.9 -146.0 -95.3 98.5 141.1 444.7
 ARG-173   HIS-174  10.3 8.1 89.9 -30.9 69.2 91.9 109.3
 HIS-174   THR-175  13.0 9.9 6.2 51.2 122.7 58.0 29.9
 THR-175   ASP-176  16.4 13.4 45.5 -44.4 55.7 24.5 -3.7
 ASP-176   ASP-177  19.0 14.0 65.0 -150.0 120.5 66.1 -52.9
 ASP-177   GLU-178  22.4 16.4 -48.3 -26.6 6.1 103.4 152.2
 GLU-178   MET-179  20.9 15.1 111.2 4.6 106.0 118.7 -437.1
 VAL-183   ALA-184  25.4 16.9 27.3 126.9 111.4 142.6 -307.6
 ALA-184   THR-185  23.3 18.0 177.1 -11.4 59.1 100.3 613.5
 THR-185   ARG-186  20.4 20.1 175.3 43.1 56.0 84.6 -215.2
 ARG-186   TRP-187  22.7 23.7 -42.3 -0.1 60.8 49.7 76.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-323   ASP-324  12.9 10.8 37.9 -59.2 7.0 10.7 -60.5
 GLU-328   SER-329  5.8 7.7 -159.4 -49.0 168.4 171.9 465.2
 ARG-330   ASP-331  5.4 3.7 12.7 21.8 69.2 91.9 19.6
 ASP-331   LEU-332  3.1 7.5 74.6 60.1 96.7 158.8 -337.6
 ASP-335   GLU-336  11.3 11.0 9.7 -1.5 102.5 100.3 -11.1
 GLU-336   TRP-337  9.5 7.9 -4.4 2.5 34.9 26.6 3.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees