Proto-Oncogene Tyrosine-Protein Kinase Abl1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASN-358   PHE-359  13.3 11.3 106.5 -59.2 59.7 10.5 27.6
 PHE-359   ILE-360  10.9 10.8 15.1 -1.7 125.0 59.8 -0.3
 ILE-360   HIS-361  7.2 10.6 -1.1 -18.3 96.4 141.4 -2.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-419   SER-420  6.1 11.4 5.9 -21.5 88.3 27.0 -7.4
 SER-420   ASP-421  2.6 12.0 45.2 128.8 76.8 54.6 60.8
 ASP-421   VAL-422  3.5 9.9 -125.3 -15.2 176.5 131.4 -76.4
 VAL-422   TRP-423  4.0 7.5 -157.5 -9.9 65.5 42.9 -50.7
 VAL-422   TRP-423  4.0 7.5 -157.5 -9.9 65.5 42.9 -50.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-422   TRP-423  4.0 7.5 -157.5 -9.9 65.5 42.9 -50.7
 VAL-422   TRP-423  4.0 7.5 -157.5 -9.9 65.5 42.9 -50.7
 TRP-423   ALA-424  0.8 7.5 21.2 -3.0 90.4 144.8 140.9
 ALA-424   PHE-425  2.9 8.2 -16.0 -6.2 48.8 94.0 -138.3
 PHE-425   GLY-426  4.7 11.7 2.1 1.2 153.6 86.3 129.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-444   LEU-445  18.9 9.6 -175.8 -25.6 65.2 66.7 41.5
 LEU-445   SER-446  16.3 12.3 -1.6 19.3 75.3 25.0 -5.8
 SER-446   GLN-447  17.9 10.8 -32.3 39.9 135.1 94.0 6.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 MET-472   ARG-473  1.1 10.7 -111.0 -9.1 98.6 81.9 68.8
 ARG-473   ALA-474  2.7 14.3 -176.7 129.5 122.8 54.3 24.1
 ALA-474   CYS-475  5.0 16.3 85.5 107.1 14.2 135.7 -65.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees