Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-683   LYS-684  9.1 9.1 -15.2 19.1 71.1 68.1 -213.3
 LYS-684   GLU-685  12.5 12.4 -15.5 -4.2 14.2 18.4 530.4
 GLU-685   THR-686  13.5 13.3 5.7 -2.9 129.1 134.1 -111.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-702   TYR-703  12.0 11.9 -25.8 20.7 128.8 134.6 -99.8
 TYR-703   LYS-704  9.3 9.6 22.7 -24.9 94.0 98.7 135.7
 LYS-704   GLY-705  5.7 5.9 -3.5 3.9 81.0 84.7 30.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-718   ALA-719  2.1 2.1 2.8 -3.3 117.2 116.7 6.6
 ALA-719   ILE-720  5.7 5.7 14.6 -12.0 49.9 51.0 82.2
 ILE-720   LYS-721  8.3 8.6 6.5 -5.2 96.9 96.1 -42.6
 LYS-721   GLU-722  11.6 11.8 -0.3 13.9 115.5 113.2 82.4
 THR-727   SER-728  23.4 23.4 -70.3 37.6 121.3 143.8 -612.6
 SER-728   PRO-729  25.2 25.6 41.3 -19.3 34.9 37.7 435.2
 PRO-729   LYS-730  24.6 24.6 -5.4 7.1 87.2 88.5 -60.4
 LYS-730   ALA-731  24.8 24.5 -2.4 4.5 64.9 60.8 -83.2
 ALA-731   ASN-732  21.9 21.8 16.4 -15.9 55.8 57.1 -47.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLY-755   ILE-756  5.0 5.2 5.0 -0.5 111.9 113.6 -28.5
 ILE-756   CYS-757  8.7 8.9 -1.2 2.7 87.5 83.8 -39.0
 CYS-757   LEU-758  11.5 11.6 -1.8 3.6 105.3 105.0 23.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-766   GLN-767  4.9 4.9 -4.2 2.6 133.8 134.0 -51.4
 GLN-767   LEU-768  3.7 3.7 -3.2 -0.9 151.7 151.2 -95.8
 LEU-768   MET-769  4.0 4.1 0.0 3.9 72.6 71.7 82.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-987   ASP-988  8.7 8.4 -10.3 5.2 99.5 100.7 25.8
 ASP-988   ALA-989  6.9 6.5 0.6 2.0 16.2 11.2 46.7
 ALA-989   ASP-990  4.9 4.8 -0.3 -0.9 126.8 123.4 -9.1
 ASP-990   GLU-991  8.2 8.3 3.9 -7.0 107.5 105.0 17.3
 ASP-990   GLU-991  8.2 8.3 3.9 -7.0 107.5 105.0 17.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-990   GLU-991  8.2 8.3 3.9 -7.0 107.5 105.0 17.3
 ASP-990   GLU-991  8.2 8.3 3.9 -7.0 107.5 105.0 17.3
 GLU-991   TYR-992  9.8 9.8 5.6 -11.1 122.1 119.4 25.1
 TYR-992   LEU-993  7.6 7.6 -31.0 31.8 26.5 29.5 -80.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees