Mitogen-Activated Protein Kinase P38

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ARG-49   VAL-50  7.9 8.2 1.4 1.7 136.2 134.4 130.8
 VAL-50   ALA-51  6.7 6.9 -1.2 -1.0 74.2 76.3 45.2
 ALA-51   VAL-52  7.2 7.2 7.4 -6.1 166.3 168.8 -49.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ARG-57   PRO-58  14.2 14.5 13.1 -7.2 74.6 79.2 171.2
 PRO-58   PHE-59  10.8 10.9 15.5 -13.8 27.6 26.6 42.6
 PHE-59   GLN-60  10.7 11.1 -17.5 7.5 116.8 119.8 -138.5
 GLN-60   SER-61  14.5 14.8 -10.8 12.9 124.2 124.8 99.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-68   TYR-69  7.8 7.8 -3.0 1.1 92.8 95.5 18.2
 TYR-69   ARG-70  6.1 6.0 0.4 8.7 132.4 132.7 -100.2
 ARG-70   GLU-71  8.7 8.7 -6.8 1.2 25.8 23.6 119.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-72   ARG-73  3.7 3.7 0.4 2.8 91.1 92.0 -1.3
 ARG-73   LEU-74  6.3 6.2 4.4 -8.0 29.5 26.5 -6.9
 LEU-74   LEU-75  8.0 7.9 10.9 -8.3 49.4 44.0 -6.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-84   GLY-85  5.1 5.2 -3.1 -5.3 142.8 139.9 -27.8
 GLY-85   LEU-86  4.2 4.1 2.1 -17.5 68.2 70.0 0.6
 LEU-86   LEU-87  2.1 2.3 -5.3 4.5 72.8 77.7 105.4
 LEU-87   ASP-88  4.4 4.7 -5.0 4.1 140.9 144.4 -31.1
 ASP-88   VAL-89  5.4 5.5 3.8 -4.8 51.0 52.6 12.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-106   HIS-107  2.3 2.3 -3.6 10.4 160.6 153.9 -36.3
 HIS-107   LEU-108  2.3 2.5 12.9 -20.1 72.6 75.2 0.4
 LEU-108   MET-109  5.1 4.8 4.0 7.3 46.6 44.0 246.9
 MET-109   GLY-110  4.8 4.9 7.4 -35.6 38.6 47.7 -480.1
 GLY-110   ALA-111  5.8 6.8 -33.5 79.3 94.6 96.9 188.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-321   PRO-322  16.8 16.9 3.5 0.2 55.8 48.4 28.3
 PRO-322   TYR-323  17.3 17.8 -4.0 -2.8 106.6 109.9 -65.7
 TYR-323   ASP-324  14.6 15.0 -3.4 2.8 147.6 151.1 -2.0
 ASP-324   GLN-325  14.9 14.8 -2.2 -3.3 97.3 94.2 -20.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-339   LEU-340  1.6 1.5 1.0 -3.1 126.1 125.3 44.5
 LEU-340   THR-341  2.5 2.5 1.8 -4.4 152.5 156.6 17.1
 THR-341   TYR-342  1.7 1.6 5.1 -3.2 89.6 92.5 53.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees