Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  PRO-206   SER-207  2.9 3.4 2.0 -11.5 146.4 154.5 65.1  SER-207   ASP-208  2.0 2.6 -1.5 12.8 90.0 91.9 -7.8  ASP-208   THR-209  2.4 2.5 -35.0 8.5 79.6 85.7 5.2  THR-209   LEU-210  5.2 5.7 5.7 1.2 37.6 24.6 26.0  LEU-210   GLN-211  5.9 6.0 2.0 0.6 83.8 65.6 25.9  GLN-211   ALA-212  5.6 5.2 -0.2 -2.0 51.9 67.7 -13.4  ALA-212   ARG-213  7.7 8.1 -13.1 16.2 103.8 107.4 -3.9 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LEU-342   GLN-343  3.7 4.3 -12.1 3.9 14.1 27.5 66.7  GLN-343   SER-344  3.2 3.1 42.0 -33.0 114.7 88.9 -33.5  SER-344   PRO-345  4.7 4.9 -12.2 -25.0 25.6 21.6 143.1 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ALA-475   PRO-476  8.1 8.3 7.0 -3.2 64.9 69.6 7.6  PRO-476   GLY-477  6.6 7.0 68.0 -15.9 81.9 93.9 26.3  GLY-477   ARG-478  3.0 4.1 3.4 13.1 73.3 33.5 42.4  ARG-478   TYR-479  3.1 3.6 -23.4 6.7 100.9 82.1 -16.5  TYR-479   ASP-480  4.5 5.3 -15.5 3.2 116.1 132.1 -35.8  ASP-480   ILE-481  7.7 7.7 -33.4 0.6 56.3 58.7 62.2  ILE-481   MET-482  11.3 11.3 -19.6 12.8 120.9 119.7 -16.3 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees