DNA Mismatch Repair Protein Muts

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name DNA Mismatch Repair Protein Muts
  Conformer 1
(PDB)
1wb9 (A)
  Conformer 2
(PDB)
1wb9 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 570 1.51   117 - 443   520 - 772   778 - 778
2 76 0.62   16 - 114
3 76 1.03   444 - 519
4 22 0.26   773 - 777   779 - 795

Sequence


           ______________________________________________________________________________________________________________114_______ 
 1wb9(A) : SAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYTLFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISD 
         :                                                                                                                          
 1wb9(B) : ************MQQYLRLKAQHPEILLFYRMGDFYTLFYDDAKRASQLLDISLT----------pMAGIPYHAVENYLAKLVNQGESVAICE-------------rKVVRIVTPGTISD 
           ______________________________________________________________________________________________________________114_______ 

           ________________________________________________________________________________________________________________________ 
 1wb9(A) : EALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLL 
         :                                                                                                                          
 1wb9(B) : EALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1wb9(A) : QYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTAR 
         :                                                                                                                          
 1wb9(B) : QYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTAR 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________439__________________________________________ 
 1wb9(A) : PRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQ 
         :                                                                                                                          
 1wb9(B) : PRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQ 
           ___________________________________________________________________________439__________________________________________ 

           ___________________________________519__________________________________________________________________________________ 
 1wb9(A) : SHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPL 
         :                                                                                                                          
 1wb9(B) : SHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPL 
           ___________________________________519__________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1wb9(A) : NLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVG-fMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFE 
         :                                                                                                                          
 1wb9(B) : NLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGtFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFE 
           ________________________________________________________________________________________________________________________ 

           ______________________________________772__777_______________________                                                    
 1wb9(A) : LTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS                                                    
         :                                                                                                                          
 1wb9(B) : LTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS                                                    
           ______________________________________772__777_______________________                                                    

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
28.7
Translation
(A)
-0.7
Closure
(%)
89.5
Bending Residues
( green )
  114 - 117
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
12.5
Translation
(A)
0.3
Closure
(%)
99.4
Bending Residues
( green )
  439 - 449
  519 - 520
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( violet )
4
Rotation Angle
(deg)
9.9
Translation
(A)
-0.7
Closure
(%)
98.7
Bending Residues
( green )
  772 - 773
  777 - 779
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 4

Conformer 2 Contact:
Residue 4 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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