Isocitrate Dehydrogenase [Nadp] Cytoplasmic

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase [Nadp] Cytoplasmic
  Conformer 1
(PDB)
1t09 (A)
  Conformer 2
(PDB)
1t0l (D)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 262 2.06   3 - 118   134 - 139   273 - 412
2 148 1.12   119 - 133   140 - 272

Sequence


           ___________________________________________________________________________________________________________________118__ 
 1t09(A) : MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 
         :                                                                                                                          
 1t0l(D) : MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 
           ___________________________________________________________________________________________________________________118__ 

           __________133___________________________________________________________________________________________________________ 
 1t09(A) : VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 
         :                                                                                                                          
 1t0l(D) : VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 
           __________133___________________________________________________________________________________________________________ 

           __________________________269___________________________________________________________________________________________ 
 1t09(A) : AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 
         :                                                                                                                          
 1t0l(D) : AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 
           __________________________269___________________________________________________________________________________________ 

           ______________________________________________________                                                                   
 1t09(A) : EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL                                                                   
         :                                                                                                                          
 1t0l(D) : EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL                                                                   
           ______________________________________________________                                                                   

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
33.6
Translation
(A)
0.6
Closure
(%)
78.2
Bending Residues
( green )
  118 - 120
  133 - 143
  269 - 278
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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