Isocitrate Dehydrogenase [Nadp] Cytoplasmic

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase [Nadp] Cytoplasmic
  Conformer 1
(PDB)
1t09 (A)
  Conformer 2
(PDB)
1t09 (B)
  Window Length 15
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 354 2.41   8 - 135   182 - 407
2 46 1.16   136 - 181

Sequence


           ________________________________________________________________________________________________________________________ 
 1t09(A) : MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 
         :                                                                                                                          
 1t09(B) : MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 
           ________________________________________________________________________________________________________________________ 

           ____________135___________________________________________181___________________________________________________________ 
 1t09(A) : VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 
         :                                                                                                                          
 1t09(B) : VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 
           ____________135___________________________________________181___________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1t09(A) : AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 
         :                                                                                                                          
 1t09(B) : AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________                                                                   
 1t09(A) : EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL                                                                   
         :                                                                                                                          
 1t09(B) : EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL                                                                   
           ______________________________________________________                                                                   

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
14.3
Translation
(A)
1.3
Closure
(%)
9.9
Bending Residues
( green )
  135 - 148
  181 - 182
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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